2EXU

Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000182	molecular_function	rDNA binding
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000785	cellular_component	chromatin
A	0000993	molecular_function	RNA polymerase II complex binding
A	0003727	molecular_function	single-stranded RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006354	biological_process	DNA-templated transcription elongation
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0006397	biological_process	mRNA processing
A	0008270	molecular_function	zinc ion binding
A	0008298	biological_process	intracellular mRNA localization
A	0010467	biological_process	gene expression
A	0010507	biological_process	negative regulation of autophagy
A	0031507	biological_process	heterochromatin formation
A	0031934	cellular_component	mating-type region heterochromatin
A	0032044	cellular_component	DSIF complex
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0033553	cellular_component	rDNA heterochromatin
A	0044877	molecular_function	protein-containing complex binding
A	0046872	molecular_function	metal ion binding
A	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
A	0140673	biological_process	transcription elongation-coupled chromatin remodeling
A	2000232	biological_process	regulation of rRNA processing
A	2001208	biological_process	negative regulation of transcription elongation by RNA polymerase I
A	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS7
A	CYS10
A	CYS24
A	CYS27

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 1001

Chain	Residue
A	LEU368
A	PRO369

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EOH A 1002

Chain	Residue
A	PRO44
A	PHE46

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD A 2001

Chain	Residue
A	LYS62
A	TRP63
A	LEU64
A	SER65
A	ARG96
A	HOH2048
A	HOH2055
A	HOH2081
A	TRP59

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
A	CYS7-CYS27

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