2EWN
Ecoli Biotin Repressor with co-repressor analog
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004077 | molecular_function | biotin--[biotin carboxyl-carrier protein] ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006768 | biological_process | biotin metabolic process |
| A | 0009102 | biological_process | biotin biosynthetic process |
| A | 0009374 | molecular_function | biotin binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0017053 | cellular_component | transcription repressor complex |
| A | 0036211 | biological_process | protein modification process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004077 | molecular_function | biotin--[biotin carboxyl-carrier protein] ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006768 | biological_process | biotin metabolic process |
| B | 0009102 | biological_process | biotin biosynthetic process |
| B | 0009374 | molecular_function | biotin binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0017053 | cellular_component | transcription repressor complex |
| B | 0036211 | biological_process | protein modification process |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE BTX B 500 |
| Chain | Residue |
| B | SER89 |
| B | LYS122 |
| B | TRP123 |
| B | PHE124 |
| B | ASP176 |
| B | LYS183 |
| B | GLY186 |
| B | ILE187 |
| B | ALA205 |
| B | GLY206 |
| B | ASN208 |
| B | THR90 |
| B | VAL218 |
| B | ASN220 |
| B | GLN221 |
| B | TRP223 |
| B | GLU313 |
| B | ASN91 |
| B | GLN112 |
| B | GLY115 |
| B | ARG116 |
| B | GLY117 |
| B | ARG118 |
| B | ARG121 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE BTX A 501 |
| Chain | Residue |
| A | SER89 |
| A | THR90 |
| A | GLN112 |
| A | GLY115 |
| A | ARG116 |
| A | GLY117 |
| A | ARG118 |
| A | ARG121 |
| A | LYS122 |
| A | TRP123 |
| A | PHE124 |
| A | ASP176 |
| A | GLY186 |
| A | ILE187 |
| A | LEU188 |
| A | ALA205 |
| A | GLY206 |
| A | ASN208 |
| A | VAL218 |
| A | ASN220 |
| A | GLN221 |
| A | TRP223 |
| A | HOH503 |
| A | HOH525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 374 |
| Details | Domain: {"description":"BPL/LPL catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01067","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00978","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00978","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11353844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1409631","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
