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2ERC

CRYSTAL STRUCTURE OF ERMC' A RRNA-METHYL TRANSFERASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000154biological_processrRNA modification
A0000179molecular_functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
A0003723molecular_functionRNA binding
A0005829cellular_componentcytosol
A0008168molecular_functionmethyltransferase activity
A0016740molecular_functiontransferase activity
A0031167biological_processrRNA methylation
A0032259biological_processmethylation
A0046677biological_processresponse to antibiotic
A0052910molecular_function23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
B0000154biological_processrRNA modification
B0000179molecular_functionrRNA (adenine-N6,N6-)-dimethyltransferase activity
B0003723molecular_functionRNA binding
B0005829cellular_componentcytosol
B0008168molecular_functionmethyltransferase activity
B0016740molecular_functiontransferase activity
B0031167biological_processrRNA methylation
B0032259biological_processmethylation
B0046677biological_processresponse to antibiotic
B0052910molecular_function23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
Functional Information from PROSITE/UniProt
site_idPS01131
Number of Residues28
DetailsRRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. IFEiGSGkGhFTlelVqrcnf...VtAIEiD
ChainResidueDetails
AILE34-ASP61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING:
ChainResidueDetails
AASN11
BGLU59
BASP84
BASN101
AILE13
AGLY38
AGLU59
AASP84
AASN101
BASN11
BILE13
BGLY38

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 898
ChainResidueDetails
AGLY38activator, electrostatic stabiliser
AGLU59activator, electrostatic stabiliser
AASN101activator, electrostatic stabiliser
ATYR104activator, electrostatic stabiliser
APHE163activator, electrostatic stabiliser

site_idMCSA2
Number of Residues5
DetailsM-CSA 898
ChainResidueDetails
BGLY38activator, electrostatic stabiliser
BGLU59activator, electrostatic stabiliser
BASN101activator, electrostatic stabiliser
BTYR104activator, electrostatic stabiliser
BPHE163activator, electrostatic stabiliser

218853

PDB entries from 2024-04-24

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