2EJW
Homoserine Dehydrogenase from Thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004412 | molecular_function | homoserine dehydrogenase activity |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0009086 | biological_process | methionine biosynthetic process |
| E | 0009088 | biological_process | threonine biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0050661 | molecular_function | NADP binding |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004412 | molecular_function | homoserine dehydrogenase activity |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0009086 | biological_process | methionine biosynthetic process |
| F | 0009088 | biological_process | threonine biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 2003 |
| Chain | Residue |
| A | GLU121 |
| A | VAL124 |
| A | ALA126 |
| A | THR128 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 2002 |
| Chain | Residue |
| A | HOH2807 |
| A | ASP68 |
| A | HOH2622 |
| A | HOH2652 |
| A | HOH2663 |
| A | HOH2779 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 A 2602 |
| Chain | Residue |
| A | ASN150 |
| A | GLY151 |
| A | THR152 |
| A | ASP191 |
| A | LYS195 |
| A | GLY288 |
| A | HOH2772 |
| A | HOH2820 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 2001 |
| Chain | Residue |
| A | MET1 |
| B | GLU114 |
| B | HOH2504 |
| B | HOH2509 |
| B | HOH2517 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 2004 |
| Chain | Residue |
| B | GLU121 |
| B | VAL124 |
| B | ALA126 |
| B | THR128 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 2006 |
| Chain | Residue |
| E | GLU121 |
| E | VAL124 |
| E | MET125 |
| E | ALA126 |
| E | THR128 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG E 2007 |
| Chain | Residue |
| E | GLU24 |
| E | HOH2639 |
| E | HOH2652 |
| E | HOH2700 |
| F | HOH2729 |
| F | HOH2776 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NO3 E 2601 |
| Chain | Residue |
| E | GLY151 |
| E | THR152 |
| E | TYR178 |
| E | LYS195 |
| E | GLY288 |
| E | ALA289 |
| E | HOH2702 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 2005 |
| Chain | Residue |
| F | GLU121 |
| F | VAL124 |
| F | MET125 |
| F | ALA126 |
| F | THR128 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NO3 F 2603 |
| Chain | Residue |
| F | ASN150 |
| F | GLY151 |
| F | THR152 |
| F | LYS195 |
| F | GLY288 |
| F | ALA289 |
| F | HOH2654 |
| F | HOH2832 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 2501 |
| Chain | Residue |
| B | GLY151 |
| B | TYR178 |
| B | ASN270 |
| B | PRO287 |
| B | GLY288 |
| B | HOH2543 |
| B | HOH2646 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL E 2502 |
| Chain | Residue |
| E | GLU135 |
| E | ARG304 |
| E | HOH2602 |
| E | HOH2605 |
| E | HOH2616 |
| E | HOH2756 |
| F | ARG304 |
| F | SER307 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
| Chain | Residue | Details |
| A | ALA173-LYS195 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ebf |
| Chain | Residue | Details |
| A | LYS195 | |
| A | ASP191 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ebf |
| Chain | Residue | Details |
| B | LYS195 | |
| B | ASP191 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ebf |
| Chain | Residue | Details |
| E | LYS195 | |
| E | ASP191 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ebf |
| Chain | Residue | Details |
| F | LYS195 | |
| F | ASP191 |
