2EJV
Crystal structure of threonine 3-dehydrogenase complexed with NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006567 | biological_process | L-threonine catabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008743 | molecular_function | L-threonine 3-dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019518 | biological_process | L-threonine catabolic process to glycine |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006567 | biological_process | L-threonine catabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008743 | molecular_function | L-threonine 3-dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019518 | biological_process | L-threonine catabolic process to glycine |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS38 |
| A | HIS63 |
| A | GLU64 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | CYS93 |
| A | HIS94 |
| A | CYS96 |
| A | CYS99 |
| A | CYS107 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 501 |
| Chain | Residue |
| B | HIS63 |
| B | GLU64 |
| B | CYS38 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | CYS93 |
| B | CYS96 |
| B | CYS99 |
| B | CYS107 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD B 2350 |
| Chain | Residue |
| B | ASN152 |
| B | GLY172 |
| B | GLY174 |
| B | PRO175 |
| B | ILE176 |
| B | SER195 |
| B | ASP196 |
| B | PRO197 |
| B | ARG201 |
| B | PHE238 |
| B | SER239 |
| B | ASN241 |
| B | ALA244 |
| B | LEU261 |
| B | ILE263 |
| B | ILE286 |
| B | ALA287 |
| B | GLY288 |
| B | HOH2378 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD A 1350 |
| Chain | Residue |
| A | GLY172 |
| A | GLY174 |
| A | PRO175 |
| A | ILE176 |
| A | SER195 |
| A | ASP196 |
| A | PRO197 |
| A | ARG201 |
| A | PRO215 |
| A | PHE238 |
| A | SER239 |
| A | ASN241 |
| A | ALA244 |
| A | LEU261 |
| A | GLY262 |
| A | ILE263 |
| A | ILE286 |
| A | ALA287 |
| A | GLY288 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEfSGVveavGpgV |
| Chain | Residue | Details |
| A | GLY62-VAL76 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_00627","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of threonine 3-dehydrogenase.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}},{"source":"PDB","id":"2DQ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2EJV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of threonine 3-dehydrogenase.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2007","submissionDatabase":"PDB data bank","title":"Crystal structure of threonine 3-dehydrogenase.","authoringGroup":["RIKEN structural genomics initiative (RSGI)"]}},{"source":"PDB","id":"2EJV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom","evidences":[{"source":"HAMAP-Rule","id":"MF_00627","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| A | THR40 | |
| A | GLY39 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| B | THR40 | |
| B | GLY39 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| A | THR40 | |
| A | HIS43 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1teh |
| Chain | Residue | Details |
| B | THR40 | |
| B | HIS43 |
