Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EJ0

Crystal Structure of T.th.HB8 Branched-Chain Amino Acid Aminotransferase with Pyridoxamine 5'-phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
A	0006520	biological_process	amino acid metabolic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
A	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
A	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
B	0006520	biological_process	amino acid metabolic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
B	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
B	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity
C	0003824	molecular_function	catalytic activity
C	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
C	0006520	biological_process	amino acid metabolic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009098	biological_process	L-leucine biosynthetic process
C	0009099	biological_process	L-valine biosynthetic process
C	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
C	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
C	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity
D	0003824	molecular_function	catalytic activity
D	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
D	0006520	biological_process	amino acid metabolic process
D	0009081	biological_process	branched-chain amino acid metabolic process
D	0009098	biological_process	L-leucine biosynthetic process
D	0009099	biological_process	L-valine biosynthetic process
D	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
D	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
D	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity
E	0003824	molecular_function	catalytic activity
E	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
E	0006520	biological_process	amino acid metabolic process
E	0009081	biological_process	branched-chain amino acid metabolic process
E	0009098	biological_process	L-leucine biosynthetic process
E	0009099	biological_process	L-valine biosynthetic process
E	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
E	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
E	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity
F	0003824	molecular_function	catalytic activity
F	0004084	molecular_function	branched-chain-amino-acid:2-oxoglutarate transaminase activity
F	0006520	biological_process	amino acid metabolic process
F	0009081	biological_process	branched-chain amino acid metabolic process
F	0009098	biological_process	L-leucine biosynthetic process
F	0009099	biological_process	L-valine biosynthetic process
F	0052654	molecular_function	L-leucine:2-oxoglutarate transaminase activity
F	0052655	molecular_function	L-valine:2-oxoglutarate transaminase activity
F	0052656	molecular_function	L-isoleucine:2-oxoglutarate transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP A 3413

Chain	Residue
A	ARG59
A	GLY255
A	THR256
A	HOH3432
A	HOH3464
A	HOH3482
A	ARG148
A	TYR164
A	GLU193
A	GLY196
A	LEU216
A	GLY218
A	ILE219
A	THR220

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP B 3913

Chain	Residue
B	ARG59
B	ARG148
B	TYR164
B	GLU193
B	GLY196
B	LEU216
B	GLY218
B	ILE219
B	THR220
B	GLY255
B	THR256
B	HOH3924
B	HOH3995
B	HOH4027

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP C 4413

Chain	Residue
C	ARG59
C	ARG148
C	TYR164
C	GLU193
C	GLY196
C	LEU216
C	GLY218
C	ILE219
C	THR220
C	GLY255
C	THR256
C	HOH5422
C	HOH5448
C	HOH5523

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP D 1913

Chain	Residue
D	ARG59
D	ARG148
D	TYR164
D	GLU193
D	GLY196
D	LEU216
D	GLY218
D	ILE219
D	THR220
D	GLY255
D	THR256
D	HOH1922
D	HOH1968
D	HOH2035

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP E 2413

Chain	Residue
E	ARG59
E	ARG148
E	TYR164
E	GLU193
E	GLY196
E	LEU216
E	GLY218
E	ILE219
E	THR220
E	GLY255
E	THR256
E	HOH2423
E	HOH2480
E	HOH2565

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP F 2913

Chain	Residue
F	ARG59
F	ARG148
F	TYR164
F	GLU193
F	GLY196
F	LEU216
F	GLY218
F	ILE219
F	THR220
F	GLY255
F	THR256
F	HOH2918
F	HOH2988
F	HOH2996

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MPD A 3414

Chain	Residue
A	ARG52
A	GLU55
A	GLU217
A	GLY218
A	ILE219
A	ASP222
A	HOH3473
A	HOH3506
C	ARG203
C	ASP204

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 2415

Chain	Residue
E	ARG295
A	ASP230
A	GLU297
A	HOH3479
A	HOH3630
E	GLU289

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD B 3914

Chain	Residue
A	ARG203
A	ASP204
B	ARG52
B	GLU55
B	GLU217
B	GLY218
B	ILE219
B	ASP222
B	HOH3980

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD C 5414

Chain	Residue
B	ARG203
B	ASP204
C	ARG52
C	GLU55
C	GLU217
C	GLY218
C	ILE219
C	ASP222
C	HOH5461

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD D 1914

Chain	Residue
B	LEU107
D	TYR95
D	TRP124
D	ALA257
D	HOH2035

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD D 1915

Chain	Residue
D	ARG52
D	GLU55
D	GLU217
D	GLY218
D	ILE219
D	ASP222
D	HOH1995
F	ARG203
F	ASP204

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPD E 2414

Chain	Residue
D	ARG203
D	ASP204
E	ARG52
E	GLU55
E	GLU217
E	GLY218
E	ILE219
E	ASP222
E	HOH2459

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD F 2914

Chain	Residue
C	GLU289
C	ARG294
C	ARG295
C	HOH5667
F	ASP230
F	GLU297
F	HOH2981

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
A	LYS159

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
B	LYS159

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
C	LYS159

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
D	LYS159

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
E	LYS159

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1iyd

Chain	Residue	Details
F	LYS159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)