Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2EHO

Crystal structure of human GINS complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000811	cellular_component	GINS complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0071162	cellular_component	CMG complex
B	0000811	cellular_component	GINS complex
B	0006260	biological_process	DNA replication
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000811	cellular_component	GINS complex
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0071162	cellular_component	CMG complex
D	0000811	cellular_component	GINS complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0071162	cellular_component	CMG complex
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000811	cellular_component	GINS complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0071162	cellular_component	CMG complex
F	0000811	cellular_component	GINS complex
F	0006260	biological_process	DNA replication
G	0000727	biological_process	double-strand break repair via break-induced replication
G	0000811	cellular_component	GINS complex
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0006260	biological_process	DNA replication
G	0071162	cellular_component	CMG complex
H	0000811	cellular_component	GINS complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0006260	biological_process	DNA replication
H	0006270	biological_process	DNA replication initiation
H	0071162	cellular_component	CMG complex
I	0000727	biological_process	double-strand break repair via break-induced replication
I	0000811	cellular_component	GINS complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0006260	biological_process	DNA replication
I	0006261	biological_process	DNA-templated DNA replication
I	0071162	cellular_component	CMG complex
J	0000811	cellular_component	GINS complex
J	0006260	biological_process	DNA replication
K	0000727	biological_process	double-strand break repair via break-induced replication
K	0000811	cellular_component	GINS complex
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0006260	biological_process	DNA replication
K	0071162	cellular_component	CMG complex
L	0000811	cellular_component	GINS complex
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0006260	biological_process	DNA replication
L	0006270	biological_process	DNA replication initiation
L	0071162	cellular_component	CMG complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 I 1001

Chain	Residue
I	ARG207
I	LYS209

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 I 1002

Chain	Residue
I	SER139
I	LYS142
I	ASN143

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 1003

Chain	Residue
I	ARG176
I	ASN36
I	PHE172
I	LEU173
I	ARG174

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 1004

Chain	Residue
F	MSE1
F	PHE2
H	PHE46

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 1005

Chain	Residue
D	GLN177
F	PRO99
F	ASN100
F	ALA101

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 J 1006

Chain	Residue
J	MSE1
J	GLU35
J	ALA38

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 K 1007

Chain	Residue
K	LEU14
K	VAL15
K	THR16
K	GLU43

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 1008

Chain	Residue
L	ARG81
L	VAL86
L	PHE126
L	SER128
L	HOH1025

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 1009

Chain	Residue
C	THR16
C	LEU61
C	GLU64
L	ALA102

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1010

Chain	Residue
E	ARG94
E	MSE98
F	ARG88
F	TRP92
H	PHE6

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 1011

Chain	Residue
E	PRO115

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 1012

Chain	Residue
E	ARG131

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1013

Chain	Residue
E	SER139
E	LYS142
E	ASN143

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 1014

Chain	Residue
E	VAL144
F	GLU109

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1015

Chain	Residue
E	ASP168
E	ARG207
E	LYS209

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1016

Chain	Residue
B	HIS14
D	LEU26
D	GLU170
F	HIS105

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1017

Chain	Residue
A	ARG160
B	ARG73
D	PHE19

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)