2EHH
Crystal structure of dihydrodipicolinate synthase from aquifex aeolicus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0044281 | biological_process | small molecule metabolic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0009085 | biological_process | lysine biosynthetic process |
| C | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| C | 0044281 | biological_process | small molecule metabolic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0009085 | biological_process | lysine biosynthetic process |
| D | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0044281 | biological_process | small molecule metabolic process |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| E | 0009085 | biological_process | lysine biosynthetic process |
| E | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019877 | biological_process | diaminopimelate biosynthetic process |
| E | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1001 |
| Chain | Residue |
| A | TYR105 |
| A | HOH1003 |
| A | HOH1077 |
| A | HOH1083 |
| C | ASN79 |
| C | TYR105 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 E 1002 |
| Chain | Residue |
| E | HOH1004 |
| E | HOH1084 |
| D | ASN79 |
| D | TYR105 |
| E | TYR105 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00418 |
| Chain | Residue | Details |
| A | TYR132 | |
| C | TYR132 | |
| D | TYR132 | |
| E | TYR132 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_00418 |
| Chain | Residue | Details |
| A | LYS161 | |
| C | LYS161 | |
| D | LYS161 | |
| E | LYS161 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00418 |
| Chain | Residue | Details |
| A | THR44 | |
| A | ILE203 | |
| C | THR44 | |
| C | ILE203 | |
| D | THR44 | |
| D | ILE203 | |
| E | THR44 | |
| E | ILE203 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | SITE: Part of a proton relay during catalysis => ECO:0000255|HAMAP-Rule:MF_00418 |
| Chain | Residue | Details |
| A | THR43 | |
| A | TYR106 | |
| C | THR43 | |
| C | TYR106 | |
| D | THR43 | |
| D | TYR106 | |
| E | THR43 | |
| E | TYR106 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| A | LYS161 | |
| A | ARG137 | |
| A | TYR132 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| C | LYS161 | |
| C | ARG137 | |
| C | TYR132 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| D | LYS161 | |
| D | ARG137 | |
| D | TYR132 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| E | LYS161 | |
| E | ARG137 | |
| E | TYR132 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| A | THR44 | |
| A | THR43 | |
| A | LYS161 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| C | THR44 | |
| C | THR43 | |
| C | LYS161 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| D | THR44 | |
| D | THR43 | |
| D | LYS161 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dhp |
| Chain | Residue | Details |
| E | THR44 | |
| E | THR43 | |
| E | LYS161 |
