Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2E9X

The crystal structure of human GINS core complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000811	cellular_component	GINS complex
A	0006260	biological_process	DNA replication
B	0000228	cellular_component	nuclear chromosome
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000811	cellular_component	GINS complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0032993	cellular_component	protein-DNA complex
B	0071162	cellular_component	CMG complex
C	0000811	cellular_component	GINS complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0071162	cellular_component	CMG complex
C	1902975	biological_process	mitotic DNA replication initiation
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000811	cellular_component	GINS complex
D	0001833	biological_process	inner cell mass cell proliferation
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0071162	cellular_component	CMG complex
E	0000811	cellular_component	GINS complex
E	0006260	biological_process	DNA replication
F	0000228	cellular_component	nuclear chromosome
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0000811	cellular_component	GINS complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0032993	cellular_component	protein-DNA complex
F	0071162	cellular_component	CMG complex
G	0000811	cellular_component	GINS complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0006260	biological_process	DNA replication
G	0006268	biological_process	DNA unwinding involved in DNA replication
G	0071162	cellular_component	CMG complex
G	1902975	biological_process	mitotic DNA replication initiation
H	0000727	biological_process	double-strand break repair via break-induced replication
H	0000811	cellular_component	GINS complex
H	0001833	biological_process	inner cell mass cell proliferation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0006260	biological_process	DNA replication
H	0006261	biological_process	DNA-templated DNA replication
H	0006268	biological_process	DNA unwinding involved in DNA replication
H	0071162	cellular_component	CMG complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	ASP139
A	MET140
A	LYS141
A	HOH1038

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ARG91
A	GLY95
A	SER96
A	HOH1013
A	HOH1014

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	PRO99
A	ASN100
A	HOH1025
B	ARG137
F	ASP133
F	ARG137
F	HOH1013

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 1004

Chain	Residue
H	ARG174
H	ARG176

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 1005

Chain	Residue
C	LYS1090
C	TRP1096
F	ARG75
F	ARG79

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 1006

Chain	Residue
E	ASP139
E	MET140
E	LYS141
E	HOH1030

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
D	MET1
H	MET1

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in DNA replication complex GINS protein SLD5, N-terminally processed => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
D	THR2
H	THR2

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
D	SER12
D	SER16
H	SER12
H	SER16

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
B	LYS109
F	LYS109

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)