2E7F
5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 Angsrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008705 | molecular_function | methionine synthase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0015977 | biological_process | carbon fixation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0032259 | biological_process | methylation |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050667 | biological_process | homocysteine metabolic process |
| A | 0071267 | biological_process | L-methionine salvage |
| A | 0102036 | molecular_function | methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008705 | molecular_function | methionine synthase activity |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0015977 | biological_process | carbon fixation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0031419 | molecular_function | cobalamin binding |
| B | 0032259 | biological_process | methylation |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050667 | biological_process | homocysteine metabolic process |
| B | 0071267 | biological_process | L-methionine salvage |
| B | 0102036 | molecular_function | methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 3001 |
| Chain | Residue |
| A | GLY222 |
| A | ASP224 |
| A | HOH3032 |
| A | HOH3053 |
| A | HOH3059 |
| A | HOH3095 |
| A | HOH3210 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 4001 |
| Chain | Residue |
| B | ASP224 |
| B | HOH4083 |
| B | HOH4220 |
| B | HOH4221 |
| B | LYS184 |
| B | GLY222 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE C2F A 3000 |
| Chain | Residue |
| A | GLU6 |
| A | MET11 |
| A | PHE12 |
| A | ASP75 |
| A | ASN96 |
| A | ILE120 |
| A | ASP160 |
| A | GLY196 |
| A | SER198 |
| A | ASN199 |
| A | GLN202 |
| A | ARG207 |
| A | ILE227 |
| A | HOH3002 |
| A | HOH3003 |
| A | HOH3054 |
| A | HOH3148 |
| A | HOH3176 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE C2F B 4000 |
| Chain | Residue |
| B | MET11 |
| B | ASP75 |
| B | ASN96 |
| B | ILE120 |
| B | ASP160 |
| B | GLY196 |
| B | SER198 |
| B | ASN199 |
| B | GLN202 |
| B | ARG207 |
| B | HOH4002 |
| B | HOH4003 |
| B | HOH4036 |
| B | HOH4066 |
| B | HOH4120 |
| B | HOH4213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 490 |
| Details | Domain: {"description":"Pterin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00334","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer"} |
| Chain | Residue | Details |
