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2E3T

Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000255biological_processallantoin metabolic process
A0001933biological_processnegative regulation of protein phosphorylation
A0001937biological_processnegative regulation of endothelial cell proliferation
A0004854molecular_functionxanthine dehydrogenase activity
A0004855molecular_functionxanthine oxidase activity
A0005506molecular_functioniron ion binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0006147biological_processguanine catabolic process
A0006148biological_processinosine catabolic process
A0006149biological_processdeoxyinosine catabolic process
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006161biological_processdeoxyguanosine catabolic process
A0006196biological_processAMP catabolic process
A0006204biological_processIMP catabolic process
A0007595biological_processlactation
A0009114biological_processhypoxanthine catabolic process
A0009115biological_processxanthine catabolic process
A0010044biological_processresponse to aluminum ion
A0010629biological_processnegative regulation of gene expression
A0016226biological_processiron-sulfur cluster assembly
A0016491molecular_functionoxidoreductase activity
A0016529cellular_componentsarcoplasmic reticulum
A0030856biological_processregulation of epithelial cell differentiation
A0032496biological_processresponse to lipopolysaccharide
A0034465biological_processresponse to carbon monoxide
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043546molecular_functionmolybdopterin cofactor binding
A0043605biological_processamide catabolic process
A0045602biological_processnegative regulation of endothelial cell differentiation
A0046038biological_processGMP catabolic process
A0046055biological_processdGMP catabolic process
A0046059biological_processdAMP catabolic process
A0046872molecular_functionmetal ion binding
A0050421molecular_functionnitrite reductase (NO-forming) activity
A0050660molecular_functionflavin adenine dinucleotide binding
A0051536molecular_functioniron-sulfur cluster binding
A0051537molecular_function2 iron, 2 sulfur cluster binding
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070674molecular_functionhypoxanthine dehydrogenase activity
A0070675molecular_functionhypoxanthine oxidase activity
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071949molecular_functionFAD binding
A0097184biological_processresponse to azide
A1900745biological_processpositive regulation of p38MAPK cascade
A1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001213biological_processnegative regulation of vasculogenesis
B0000255biological_processallantoin metabolic process
B0001933biological_processnegative regulation of protein phosphorylation
B0001937biological_processnegative regulation of endothelial cell proliferation
B0004854molecular_functionxanthine dehydrogenase activity
B0004855molecular_functionxanthine oxidase activity
B0005506molecular_functioniron ion binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0006147biological_processguanine catabolic process
B0006148biological_processinosine catabolic process
B0006149biological_processdeoxyinosine catabolic process
B0006154biological_processadenosine catabolic process
B0006157biological_processdeoxyadenosine catabolic process
B0006161biological_processdeoxyguanosine catabolic process
B0006196biological_processAMP catabolic process
B0006204biological_processIMP catabolic process
B0007595biological_processlactation
B0009114biological_processhypoxanthine catabolic process
B0009115biological_processxanthine catabolic process
B0010044biological_processresponse to aluminum ion
B0010629biological_processnegative regulation of gene expression
B0016226biological_processiron-sulfur cluster assembly
B0016491molecular_functionoxidoreductase activity
B0016529cellular_componentsarcoplasmic reticulum
B0030856biological_processregulation of epithelial cell differentiation
B0032496biological_processresponse to lipopolysaccharide
B0034465biological_processresponse to carbon monoxide
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043546molecular_functionmolybdopterin cofactor binding
B0043605biological_processamide catabolic process
B0045602biological_processnegative regulation of endothelial cell differentiation
B0046038biological_processGMP catabolic process
B0046055biological_processdGMP catabolic process
B0046059biological_processdAMP catabolic process
B0046872molecular_functionmetal ion binding
B0050421molecular_functionnitrite reductase (NO-forming) activity
B0050660molecular_functionflavin adenine dinucleotide binding
B0051536molecular_functioniron-sulfur cluster binding
B0051537molecular_function2 iron, 2 sulfur cluster binding
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070674molecular_functionhypoxanthine dehydrogenase activity
B0070675molecular_functionhypoxanthine oxidase activity
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0071949molecular_functionFAD binding
B0097184biological_processresponse to azide
B1900745biological_processpositive regulation of p38MAPK cascade
B1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B2001213biological_processnegative regulation of vasculogenesis
Functional Information from PROSITE/UniProt
site_idPS00197
Number of Residues9
Details2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CGEGGCGAC
ChainResidueDetails
ACYS43-CYS51

site_idPS00559
Number of Residues36
DetailsMOLYBDOPTERIN_EUK Eukaryotic molybdopterin oxidoreductases signature. GFggKetrstvvstala..LaahKTgrpVrCmlDRdeD
ChainResidueDetails
AGLY797-ASP832

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
APRO1262
BPRO1262

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:17301076, ECO:0007744|PDB:2E3T
ChainResidueDetails
AGLY44
BGLY49
BTHR52
BLEU74
BGLY113
BTHR116
BARG148
BTHR150
AGLY49
ATHR52
ALEU74
AGLY113
ATHR116
AARG148
ATHR150
BGLY44

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:15878860, ECO:0000269|PubMed:17301076
ChainResidueDetails
AVAL257
AILE347
ALEU360
ALEU404
BVAL257
BILE347
BLEU360
BLEU404

site_idSWS_FT_FI4
Number of Residues14
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AALA337
BASN768
BGLY799
BGLY913
BGLY915
BSER1080
AGLN422
AASN768
AGLY799
AGLY913
AGLY915
ASER1080
BALA337
BGLN422

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING:
ChainResidueDetails
ATHR803
AALA881
ALEU1011
BTHR803
BALA881
BLEU1011

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fiq
ChainResidueDetails
AGLU1261

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fiq
ChainResidueDetails
BGLU1261

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1fiq
ChainResidueDetails
AARG912
AGLN767

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1fiq
ChainResidueDetails
BARG912
BGLN767

223166

PDB entries from 2024-07-31

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