2E32

Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006516	biological_process	glycoprotein catabolic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0030246	molecular_function	carbohydrate binding
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031249	molecular_function	denatured protein binding
A	0031396	biological_process	regulation of protein ubiquitination
A	0036503	biological_process	ERAD pathway
A	0043197	cellular_component	dendritic spine
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0098890	cellular_component	extrinsic component of postsynaptic membrane
A	0098978	cellular_component	glutamatergic synapse
A	0099576	biological_process	regulation of protein catabolic process at postsynapse, modulating synaptic transmission
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000209	biological_process	protein polyubiquitination
B	0000785	cellular_component	chromatin
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006879	biological_process	intracellular iron ion homeostasis
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008013	molecular_function	beta-catenin binding
B	0010564	biological_process	regulation of cell cycle process
B	0010824	biological_process	regulation of centrosome duplication
B	0014033	biological_process	neural crest cell differentiation
B	0016567	biological_process	protein ubiquitination
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019904	molecular_function	protein domain specific binding
B	0030510	biological_process	regulation of BMP signaling pathway
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
B	0031507	biological_process	heterochromatin formation
B	0031519	cellular_component	PcG protein complex
B	0032006	biological_process	regulation of TOR signaling
B	0042752	biological_process	regulation of circadian rhythm
B	0042981	biological_process	regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0050727	biological_process	regulation of inflammatory response
B	0051124	biological_process	synaptic assembly at neuromuscular junction
B	0051298	biological_process	centrosome duplication
B	0051457	biological_process	maintenance of protein location in nucleus
B	0051726	biological_process	regulation of cell cycle
B	0060173	biological_process	limb development
B	0060271	biological_process	cilium assembly
B	0070936	biological_process	protein K48-linked ubiquitination
B	0097602	molecular_function	cullin family protein binding
B	0140677	molecular_function	molecular function activator activity
B	0160072	molecular_function	ubiquitin ligase complex scaffold activity
B	1901524	biological_process	regulation of mitophagy
B	1904415	biological_process	regulation of xenophagy
B	1990444	molecular_function	F-box domain binding
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	1990757	molecular_function	ubiquitin ligase activator activity
B	2000001	biological_process	regulation of DNA damage checkpoint
C	0001540	molecular_function	amyloid-beta binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006516	biological_process	glycoprotein catabolic process
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030246	molecular_function	carbohydrate binding
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031249	molecular_function	denatured protein binding
C	0031396	biological_process	regulation of protein ubiquitination
C	0036503	biological_process	ERAD pathway
C	0043197	cellular_component	dendritic spine
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0098890	cellular_component	extrinsic component of postsynaptic membrane
C	0098978	cellular_component	glutamatergic synapse
C	0099576	biological_process	regulation of protein catabolic process at postsynapse, modulating synaptic transmission
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000209	biological_process	protein polyubiquitination
D	0000785	cellular_component	chromatin
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006879	biological_process	intracellular iron ion homeostasis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008013	molecular_function	beta-catenin binding
D	0010564	biological_process	regulation of cell cycle process
D	0010824	biological_process	regulation of centrosome duplication
D	0014033	biological_process	neural crest cell differentiation
D	0016567	biological_process	protein ubiquitination
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019904	molecular_function	protein domain specific binding
D	0030510	biological_process	regulation of BMP signaling pathway
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031507	biological_process	heterochromatin formation
D	0031519	cellular_component	PcG protein complex
D	0032006	biological_process	regulation of TOR signaling
D	0042752	biological_process	regulation of circadian rhythm
D	0042981	biological_process	regulation of apoptotic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0050727	biological_process	regulation of inflammatory response
D	0051124	biological_process	synaptic assembly at neuromuscular junction
D	0051298	biological_process	centrosome duplication
D	0051457	biological_process	maintenance of protein location in nucleus
D	0051726	biological_process	regulation of cell cycle
D	0060173	biological_process	limb development
D	0060271	biological_process	cilium assembly
D	0070936	biological_process	protein K48-linked ubiquitination
D	0097602	molecular_function	cullin family protein binding
D	0140677	molecular_function	molecular function activator activity
D	0160072	molecular_function	ubiquitin ligase complex scaffold activity
D	1901524	biological_process	regulation of mitophagy
D	1904415	biological_process	regulation of xenophagy
D	1990444	molecular_function	F-box domain binding
D	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	1990757	molecular_function	ubiquitin ligase activator activity
D	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Domain: {"description":"FBA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00482","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Important for carbohydrate binding"}

Chain

Residue

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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