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2E31

Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0006516biological_processglycoprotein catabolic process
A0008285biological_processnegative regulation of cell population proliferation
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030246molecular_functioncarbohydrate binding
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031249molecular_functiondenatured protein binding
A0031396biological_processregulation of protein ubiquitination
A0036503biological_processERAD pathway
A0043197cellular_componentdendritic spine
A0098890cellular_componentextrinsic component of postsynaptic membrane
A0098978cellular_componentglutamatergic synapse
A0099576biological_processregulation of protein catabolic process at postsynapse, modulating synaptic transmission
B0000209biological_processprotein polyubiquitination
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006338biological_processchromatin remodeling
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0008013molecular_functionbeta-catenin binding
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0019904molecular_functionprotein domain specific binding
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031519cellular_componentPcG protein complex
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051457biological_processmaintenance of protein location in nucleus
B0070936biological_processprotein K48-linked ubiquitination
B0097602molecular_functioncullin family protein binding
B0140677molecular_functionmolecular function activator activity
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1904668biological_processpositive regulation of ubiquitin protein ligase activity
B1990444molecular_functionF-box domain binding
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
BPRO132
ATYR279

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211
ChainResidueDetails
BASN143
APHE177

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER106

224004

PDB entries from 2024-08-21

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