2DHO
Crystal structure of human IPP isomerase I in space group P212121
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004452 | molecular_function | isopentenyl-diphosphate delta-isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006694 | biological_process | steroid biosynthetic process |
| A | 0006695 | biological_process | cholesterol biosynthetic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0009240 | biological_process | isopentenyl diphosphate biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016860 | molecular_function | intramolecular oxidoreductase activity |
| A | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
| A | 0033489 | biological_process | cholesterol biosynthetic process via desmosterol |
| A | 0033490 | biological_process | cholesterol biosynthetic process via lathosterol |
| A | 0035634 | biological_process | response to stilbenoid |
| A | 0036197 | biological_process | zymosterol biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1001 |
| Chain | Residue |
| A | HIS40 |
| A | HIS51 |
| A | HIS88 |
| A | GLU146 |
| A | GLU148 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1002 |
| Chain | Residue |
| A | HOH3053 |
| A | HOH3067 |
| A | HIS135 |
| A | HIS147 |
| A | HOH3030 |
| A | HOH3050 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1003 |
| Chain | Residue |
| A | LYS137 |
| A | HOH3012 |
| A | HOH3013 |
| A | HOH3016 |
| A | HOH3024 |
| A | HOH3025 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1004 |
| Chain | Residue |
| A | TYR136 |
| A | GLU148 |
| A | ASP150 |
| A | HOH3047 |
| A | HOH3190 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1005 |
| Chain | Residue |
| A | HOH3116 |
| A | HOH3148 |
| A | HOH3167 |
| A | HOH3211 |
| A | HOH3247 |
| A | HOH3271 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 1006 |
| Chain | Residue |
| A | CYS85 |
| A | ARG111 |
| A | GLU115 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 1007 |
| Chain | Residue |
| A | CYS80 |
| A | ILE193 |
| A | HOH3296 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1008 |
| Chain | Residue |
| A | GLU97 |
| A | SER99 |
| A | HOH3301 |
| A | HOH3302 |
| A | HOH3303 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 2001 |
| Chain | Residue |
| A | TYR171 |
| A | CL3001 |
| A | HOH3011 |
| A | HOH3013 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA A 2002 |
| Chain | Residue |
| A | ASP210 |
| A | ASN211 |
| A | LEU212 |
| A | ASN213 |
| A | HIS214 |
| A | HOH3045 |
| A | HOH3109 |
| A | HOH3289 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 3001 |
| Chain | Residue |
| A | LYS137 |
| A | SER170 |
| A | TYR171 |
| A | NA2001 |
| A | HOH3143 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 3002 |
| Chain | Residue |
| A | LYS113 |
| A | PRO119 |
| A | LEU120 |
| A | HOH3080 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 3003 |
| Chain | Residue |
| A | ASN63 |
| A | LYS176 |
| A | HOH3117 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 3004 |
| Chain | Residue |
| A | ASN63 |
| A | ASN92 |
| A | ARG156 |
| A | ASN213 |
| A | HOH3082 |
| A | HOH3109 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 3005 |
| Chain | Residue |
| A | GLN15 |
| A | HIS214 |
| A | ASN216 |
| A | GLN217 |
| A | HOH3308 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 3006 |
| Chain | Residue |
| A | PHE77 |
| A | PRO195 |
| A | TRP196 |
| A | HOH3163 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 3007 |
| Chain | Residue |
| A | ASN44 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 3008 |
| Chain | Residue |
| A | HOH3316 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 3009 |
| Chain | Residue |
| A | LYS198 |
| A | HOH3155 |
| A | HOH3200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Microbody targeting signal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17250851","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1i9a |
| Chain | Residue | Details |
| A | GLU148 | |
| A | CYS86 | |
| A | GLU115 | |
| A | TRP196 |
