2DHN

COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004150	molecular_function	dihydroneopterin aldolase activity
A	0006760	biological_process	folic acid-containing compound metabolic process
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PH2 A 122

Chain	Residue
A	ILE5
A	LYS100
A	HOH174
A	HOH175
A	ALA18
A	GLU22
A	VAL52
A	HIS53
A	TYR54
A	LEU72
A	LEU73
A	GLU74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:17331536, ECO:0000305|PubMed:9586996

Chain	Residue	Details
A	LYS100

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:17331536, ECO:0000305|PubMed:9586996, ECO:0007744|PDB:2NM2

Chain	Residue	Details
A	GLU22
A	TYR54
A	LEU73

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 9586996

Chain	Residue	Details
A	GLU22
A	LYS100

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 664

Chain	Residue	Details
A	GLU22	electrostatic stabiliser
A	LYS100	proton acceptor, proton donor

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