2DHN
COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006760 | biological_process | folic acid-containing compound metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PH2 A 122 |
| Chain | Residue |
| A | ILE5 |
| A | LYS100 |
| A | HOH174 |
| A | HOH175 |
| A | ALA18 |
| A | GLU22 |
| A | VAL52 |
| A | HIS53 |
| A | TYR54 |
| A | LEU72 |
| A | LEU73 |
| A | GLU74 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17331536","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9586996","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17331536","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9586996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2NM2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 9586996 |
| Chain | Residue | Details |
| A | GLU22 | |
| A | LYS100 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 664 |
| Chain | Residue | Details |
| A | GLU22 | electrostatic stabiliser |
| A | LYS100 | proton acceptor, proton donor |
