2DH4

Geranylgeranyl pyrophosphate synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
A	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0008299	biological_process	isoprenoid biosynthetic process
A	0015031	biological_process	protein transport
A	0016114	biological_process	terpenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0033384	biological_process	geranyl diphosphate biosynthetic process
A	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
B	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0008299	biological_process	isoprenoid biosynthetic process
B	0015031	biological_process	protein transport
B	0016114	biological_process	terpenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0033384	biological_process	geranyl diphosphate biosynthetic process
B	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 341

Chain	Residue
A	ASP80
A	ASP84
A	HOH368
A	HOH370
A	HOH371
A	HOH373

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 341

Chain	Residue
B	HOH386
B	HOH440
B	HOH471
B	ASP80
B	ASP84
B	HOH385

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Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. LGiiYQIrDDYlN

Chain	Residue	Details
A	LEU206-ASN218

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site_id	PS00723
Number of Residues	15
Details	POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LLiDDie..DnaplRRG

Chain	Residue	Details
A	LEU77-GLY91

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:17535895

Chain	Residue	Details
A	LYS41
A	LYS238
B	LYS41
B	ARG44
B	HIS73
B	ARG89
B	ARG90
B	LYS174
B	THR175
B	GLN211
B	ASN218
A	ARG44
B	LYS238
A	HIS73
A	ARG89
A	ARG90
A	LYS174
A	THR175
A	GLN211
A	ASN218

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895

Chain	Residue	Details
A	ASP80
A	ASP84
B	ASP80
B	ASP84

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:17535895

Chain	Residue	Details
A	LYS228
B	LYS228

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for determining product chain length

Chain	Residue	Details
A	TYR112
B	TYR112

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1fps

Chain	Residue	Details
A	TYR210
A	ARG89

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1fps

Chain	Residue	Details
B	TYR210
B	ARG89

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