2DDG
Crystal structure of uracil-DNA glycosylase in complex with AP:G containing DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033958 | molecular_function | DNA-deoxyinosine glycosylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0097506 | molecular_function | deaminated base DNA N-glycosylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 718 |
| Chain | Residue |
| A | PHE162 |
| A | HOH1191 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 719 |
| Chain | Residue |
| A | LYS30 |
| C | DT5 |
| D | DA12 |
| D | DC13 |
| D | HOH1023 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 A 220 |
| Chain | Residue |
| A | CYS16 |
| A | LEU19 |
| A | CYS115 |
| A | CYS130 |
| A | CYS13 |
| A | LEU15 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 2HP A 1001 |
| Chain | Residue |
| A | ALA59 |
| A | PRO60 |
| A | GLY61 |
| A | GLY64 |
| A | SER65 |
| A | PHE72 |
| A | ASP75 |
| A | HOH1059 |
| A | HOH1080 |
| C | ORP8 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 2HP D 1003 |
| Chain | Residue |
| A | ARG31 |
| A | GLU50 |
| D | DC13 |
| D | DA14 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1004 |
| Chain | Residue |
| A | PRO37 |
| A | TYR38 |
| A | LEU84 |
| A | GLU87 |
| A | ARG203 |
| A | HOH1019 |
| A | HOH1089 |
| A | HOH1147 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH A 1005 |
| Chain | Residue |
| A | THR202 |
| A | ARG203 |
| A | HOH1169 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH A 1006 |
| Chain | Residue |
| A | ARG128 |
| A | ALA131 |
| A | HOH1138 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EOH A 1007 |
| Chain | Residue |
| A | ARG132 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EOH A 1008 |
| Chain | Residue |
| A | HIS63 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2006","submissionDatabase":"PDB data bank","title":"Structure of family 5 uracil-DNA glycosylase bound to DNA reveals insights into the mechanism for substrate recognition and catalysis.","authors":["Kosaka H.","Nakagawa N.","Masui R.","Kuramitsu S."]}},{"source":"PDB","id":"2D3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DEM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mug |
| Chain | Residue | Details |
| A | ALA59 |
