Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0047964 | molecular_function | glyoxylate reductase (NADH) activity |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | LYS41 |
| A | TYR78 |
| A | ASN95 |
| A | ARG160 |
| A | HOH612 |
| A | HOH641 |
| A | HOH673 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | VAL76 |
| A | GLY77 |
| A | LEU100 |
| A | ARG241 |
| A | HIS288 |
| A | NAP401 |
| A | GOL501 |
| A | HOH646 |
| A | LEU53 |
| A | ALA75 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | LYS42 |
| A | VAL76 |
| A | THR104 |
| A | GLY157 |
| A | LEU158 |
| A | GLY159 |
| A | ARG160 |
| A | ILE161 |
| A | SER180 |
| A | ARG181 |
| A | THR182 |
| A | ALA211 |
| A | VAL212 |
| A | PRO213 |
| A | THR218 |
| A | ILE239 |
| A | ALA240 |
| A | ARG241 |
| A | ASP265 |
| A | VAL266 |
| A | HIS288 |
| A | GLY290 |
| A | SER291 |
| A | SO4602 |
| A | HOH603 |
| A | HOH604 |
| A | HOH605 |
| A | HOH611 |
| A | HOH612 |
| A | HOH644 |
| A | HOH646 |
| A | HOH648 |
| A | HOH651 |
| A | HOH667 |
| A | HOH682 |
| A | HOH795 |
| A | HOH814 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | MSE52 |
| A | LEU53 |
| A | TYR74 |
| A | ALA75 |
| A | TRP138 |
| A | HIS288 |
| A | MSE300 |
| A | SO4602 |
| A | HOH828 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | PRO35 |
| A | ARG36 |
| A | GLU37 |
| A | GLU324 |
| A | HOH830 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | LYS243 |
| A | PHE267 |
| A | GLU268 |
| A | GLU269 |
| A | GLU270 |
| A | HOH630 |
| A | HOH658 |
| A | HOH694 |
| A | HOH723 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | LYS151 |
| A | ASP206 |
| A | HOH619 |
| A | HOH631 |
| A | HOH759 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 505 |
| Chain | Residue |
| A | PHE125 |
| A | ARG134 |
| A | PHE143 |
| A | HOH657 |
| A | HOH829 |
| A | HOH964 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. IGIIGlGRIGqaiakrakgfnmr.ILyYS |
| Chain | Residue | Details |
| A | ILE153-SER180 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKkTaILINiARGkVVD |
| Chain | Residue | Details |
| A | MSE230-ASP246 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG241 | |
| A | GLU270 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS288 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|Ref.2 |
| Chain | Residue | Details |
| A | LEU158 | |
| A | SER180 | |
| A | ILE239 | |
| A | HIS288 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| A | LYS243 | |
| A | ASP265 | |
| A | ARG241 | |
| A | GLU270 | |
| A | HIS288 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| A | GLU270 | |
| A | HIS288 | |
