2DB3

Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003724	molecular_function	RNA helicase activity
A	0005524	molecular_function	ATP binding
B	0003676	molecular_function	nucleic acid binding
B	0003724	molecular_function	RNA helicase activity
B	0005524	molecular_function	ATP binding
C	0003676	molecular_function	nucleic acid binding
C	0003724	molecular_function	RNA helicase activity
C	0005524	molecular_function	ATP binding
D	0003676	molecular_function	nucleic acid binding
D	0003724	molecular_function	RNA helicase activity
D	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2801

Chain	Residue
A	ASP399
A	ANP2901
A	HOH2903
A	HOH3008
A	HOH3054
A	HOH3105

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 2802

Chain	Residue
B	HOH3044
B	HOH3046
B	HOH3118
B	ASP399
B	ANP2902
B	HOH2903

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 2803

Chain	Residue
C	ASP399
C	ANP2903
C	HOH2904
C	HOH2905
C	HOH3177
C	HOH3178

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 2804

Chain	Residue
D	ASP399
D	ANP2904
D	HOH2905
D	HOH3034
D	HOH3095
D	HOH3096

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ANP A 2901

Chain	Residue
A	GLY218
A	ILE219
A	PHE225
A	PHE247
A	TYR265
A	ILE267
A	GLN272
A	THR291
A	GLY292
A	SER293
A	GLY294
A	LYS295
A	THR296
A	GLU400
A	GLY552
A	ASP554
A	ARG579
A	ARG582
A	VAL583
A	MG2801
A	HOH2902
A	HOH2903
A	HOH2905
A	HOH2910
A	HOH2912
A	HOH2934
A	HOH3030

---

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ANP B 2902

Chain	Residue
B	GLY218
B	ILE219
B	PHE247
B	TYR265
B	ILE267
B	GLN272
B	THR291
B	GLY292
B	SER293
B	GLY294
B	LYS295
B	THR296
B	GLU400
B	GLY552
B	ASP554
B	ARG579
B	ARG582
B	VAL583
B	MG2802
B	HOH2924
B	HOH2935
B	HOH2945
B	HOH2948
B	HOH2971
B	HOH3044

---

site_id	AC7
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ANP C 2903

Chain	Residue
C	HOH2954
C	HOH2958
C	HOH2987
C	HOH3018
C	HOH3178
C	HOH3296
C	GLY218
C	ILE219
C	TYR265
C	ILE267
C	THR269
C	GLN272
C	THR291
C	GLY292
C	SER293
C	GLY294
C	LYS295
C	THR296
C	GLU400
C	GLY552
C	ASP554
C	ARG579
C	ARG582
C	VAL583
C	MG2803
C	HOH2905
C	HOH2906
C	HOH2934
C	HOH2937

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP D 2904

Chain	Residue
D	ILE219
D	TYR265
D	ILE267
D	GLN272
D	THR291
D	GLY292
D	SER293
D	GLY294
D	LYS295
D	THR296
D	GLU400
D	GLY552
D	ASP554
D	ARG579
D	ARG582
D	VAL583
D	MG2804
D	HOH2906
D	HOH2913
D	HOH2919
D	HOH2999
D	HOH3034
D	HOH3155

---

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmL

Chain	Residue	Details
A	VAL397-LEU405

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	708
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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