2D57
Double layered 2D crystal structure of AQUAPORIN-4 (AQP4M23) at 3.2 a resolution by electron crystallography
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006833 | biological_process | water transport |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0009992 | biological_process | intracellular water homeostasis |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0010574 | biological_process | regulation of vascular endothelial growth factor production |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015670 | biological_process | carbon dioxide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0030315 | cellular_component | T-tubule |
| A | 0031253 | cellular_component | cell projection membrane |
| A | 0032691 | biological_process | negative regulation of interleukin-1 beta production |
| A | 0032715 | biological_process | negative regulation of interleukin-6 production |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033326 | biological_process | cerebrospinal fluid secretion |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042995 | cellular_component | cell projection |
| A | 0050891 | biological_process | multicellular organismal-level water homeostasis |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060354 | biological_process | negative regulation of cell adhesion molecule production |
| A | 0070295 | biological_process | renal water absorption |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071346 | biological_process | cellular response to type II interferon |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071354 | biological_process | cellular response to interleukin-6 |
| A | 0071392 | biological_process | cellular response to estradiol stimulus |
| A | 0090660 | biological_process | cerebrospinal fluid circulation |
| A | 0097450 | cellular_component | astrocyte end-foot |
| A | 0098609 | biological_process | cell-cell adhesion |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HINPAVTVA |
| Chain | Residue | Details |
| A | HIS95-ALA103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 119 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128 |
| Chain | Residue | Details |
| A | ALA37-ILE57 | |
| A | MET70-GLY89 | |
| A | VAL116-VAL136 | |
| A | ALA156-ALA176 | |
| A | VAL185-ILE205 | |
| A | ILE232-PHE252 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128 |
| Chain | Residue | Details |
| A | ASN58-ASP69 | |
| A | THR137-THR155 | |
| A | ASN206-THR208 | |
| A | ILE223-TRP231 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 93 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128 |
| Chain | Residue | Details |
| A | HIS90-GLY93 | |
| A | VAL102-SER115 | |
| A | SER177-ASP184 | |
| A | CYS253-VAL323 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:16325200, ECO:0000269|PubMed:19406128 |
| Chain | Residue | Details |
| A | GLY94-THR101 | |
| A | GLY209-VAL222 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P55088 |
| Chain | Residue | Details |
| A | SER111 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:19800950 |
| Chain | Residue | Details |
| A | SER180 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | SER276 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:12692561, ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | SER285 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55088 |
| Chain | Residue | Details |
| A | THR289 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16641100 |
| Chain | Residue | Details |
| A | SER321 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN153 |
