2D4K

Monoclinic hen egg-white lysozyme crystallized at 313K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0008152	biological_process	metabolic process
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism
N	0003796	molecular_function	lysozyme activity
N	0003824	molecular_function	catalytic activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005737	cellular_component	cytoplasm
N	0005783	cellular_component	endoplasmic reticulum
N	0008152	biological_process	metabolic process
N	0016231	molecular_function	beta-N-acetylglucosaminidase activity
N	0016787	molecular_function	hydrolase activity
N	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
N	0016998	biological_process	cell wall macromolecule catabolic process
N	0031640	biological_process	killing of cells of another organism
N	0042742	biological_process	defense response to bacterium
N	0042802	molecular_function	identical protein binding
N	0050829	biological_process	defense response to Gram-negative bacterium
N	0050830	biological_process	defense response to Gram-positive bacterium
N	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 401

Chain	Residue
A	SER60
A	CYS64
A	SER72
A	ARG73
A	HOH402
A	HOH403

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 405

Chain	Residue
A	SER72
A	ASN65
A	ASP66
A	GLY67

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA N 406

Chain	Residue
N	SER260
N	CYS264
N	SER272
N	ARG273
N	HOH407
N	HOH408

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL N 409

Chain	Residue
N	ASN265
N	GLY267
N	ARG268
N	THR269
N	SER272
N	HOH407

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL N 410

Chain	Residue
N	TRP263

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL N 411

Chain	Residue
N	SER224
N	GLY226

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Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52
N	GLU235
N	ASP252

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	ASP101
N	ASP301

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

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site_id	MCSA2
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
N	GLU235	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
N	ASN246
N	ASP248
N	SER250
N	ASP252	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
N	ASN259

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