2D4H
Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 5GP A 593 |
| Chain | Residue |
| A | ARG48 |
| A | ASP184 |
| A | PRO241 |
| A | HOH599 |
| A | HOH606 |
| A | THR49 |
| A | GLY50 |
| A | LYS51 |
| A | SER52 |
| A | PHE65 |
| A | SER66 |
| A | GLY68 |
| A | ARG183 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 5GP B 593 |
| Chain | Residue |
| B | ARG48 |
| B | THR49 |
| B | GLY50 |
| B | LYS51 |
| B | SER52 |
| B | PHE65 |
| B | SER66 |
| B | GLY68 |
| B | ILE131 |
| B | ARG183 |
| B | ASP184 |
| B | PRO241 |
| B | HOH598 |
| B | HOH640 |
| B | HOH649 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10676968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10970849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16511497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D4H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10676968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10970849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PIM1","evidences":[{"source":"PubMed","id":"37797010","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29144452","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
