2D41
X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SNH A 1001 |
| Chain | Residue |
| A | ARG422 |
| A | TRP528 |
| A | SNH2001 |
| A | MET423 |
| A | LEU474 |
| A | HIS475 |
| A | SER476 |
| A | TYR477 |
| A | ILE482 |
| A | LEU497 |
| A | ARG501 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SNH A 2001 |
| Chain | Residue |
| A | ALA486 |
| A | ARG490 |
| A | PRO496 |
| A | LEU497 |
| A | SNH1001 |
| A | HOH2264 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SNH B 3001 |
| Chain | Residue |
| B | ARG422 |
| B | MET423 |
| B | LEU474 |
| B | HIS475 |
| B | SER476 |
| B | TYR477 |
| B | ILE482 |
| B | LEU497 |
| B | ARG501 |
| B | TRP528 |
| B | SNH4001 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SNH B 4001 |
| Chain | Residue |
| A | LYS50 |
| B | ALA486 |
| B | PRO496 |
| B | LEU497 |
| B | SNH3001 |
| B | HOH4262 |
