Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2D3B

Crystal Structure of the Maize Glutamine Synthetase complexed with AMPPNP and Methionine sulfoximine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006542	biological_process	glutamine biosynthetic process
A	0016874	molecular_function	ligase activity
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006542	biological_process	glutamine biosynthetic process
B	0016874	molecular_function	ligase activity
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006542	biological_process	glutamine biosynthetic process
C	0016874	molecular_function	ligase activity
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006542	biological_process	glutamine biosynthetic process
D	0016874	molecular_function	ligase activity
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006542	biological_process	glutamine biosynthetic process
E	0016874	molecular_function	ligase activity
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006542	biological_process	glutamine biosynthetic process
F	0016874	molecular_function	ligase activity
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006542	biological_process	glutamine biosynthetic process
G	0016874	molecular_function	ligase activity
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006542	biological_process	glutamine biosynthetic process
H	0016874	molecular_function	ligase activity
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006542	biological_process	glutamine biosynthetic process
I	0016874	molecular_function	ligase activity
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006542	biological_process	glutamine biosynthetic process
J	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 1001

Chain	Residue
A	GLU129
A	GLU199
A	ANP6001

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 1002

Chain	Residue
A	GLU129
A	HIS249
A	GLU330
A	ANP6001

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1003

Chain	Residue
A	GLU199
A	ANP6001
C	MSL5001
A	GLU131
A	GLU192

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN B 1011

Chain	Residue
B	GLU129
B	GLU199
B	ANP6002

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 1012

Chain	Residue
B	GLU129
B	HIS249
B	GLU330
B	ANP6002

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 1013

Chain	Residue
B	GLU131
B	GLU192
B	GLU199
B	ANP6002
C	MSL5002

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 1021

Chain	Residue
C	GLU129
C	GLU199
C	MN1023
C	ANP6003

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 1022

Chain	Residue
C	GLU129
C	HIS249
C	GLU330
C	ANP6003

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 1023

Chain	Residue
C	GLU131
C	GLU192
C	GLU199
C	MN1021
C	MSL5003
C	ANP6003

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 1031

Chain	Residue
D	GLU129
D	GLU199
D	MN1033
D	ANP6004

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 1032

Chain	Residue
D	GLU129
D	HIS249
D	GLU330
D	ANP6004

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 1033

Chain	Residue
C	MSL5004
D	GLU131
D	GLU192
D	GLU199
D	MN1031
D	ANP6004

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 1041

Chain	Residue
E	GLU129
E	GLU199
E	MN1043
E	ANP6005

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 1042

Chain	Residue
E	GLU129
E	HIS249
E	GLU330
E	ANP6005

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 1043

Chain	Residue
C	MSL5005
E	GLU131
E	GLU192
E	GLU199
E	MN1041
E	ANP6005

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN F 1051

Chain	Residue
F	GLU129
F	GLU199
F	MN1053
F	ANP6006

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN F 1052

Chain	Residue
F	GLU129
F	HIS249
F	GLU330
F	ANP6006

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 1053

Chain	Residue
C	MSL5007
F	GLU131
F	GLU192
F	GLU199
F	MN1051
F	ANP6006

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN G 1061

Chain	Residue
G	GLU129
G	GLU199
G	MN1063
G	ANP6007

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN G 1062

Chain	Residue
G	GLU129
G	HIS249
G	GLU330
G	ANP6007

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 1063

Chain	Residue
C	MSL5006
G	GLU131
G	GLU192
G	GLU199
G	MN1061
G	ANP6007

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN H 1071

Chain	Residue
H	GLU129
H	GLU199
H	ANP6008

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN H 1072

Chain	Residue
H	GLU330
H	ANP6008
H	GLU129
H	HIS249

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 1073

Chain	Residue
C	MSL5010
H	GLU131
H	GLU192
H	GLU199
H	ANP6008

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN I 1081

Chain	Residue
I	GLU129
I	GLU199
I	MN1083
I	ANP6009

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN I 1082

Chain	Residue
I	GLU129
I	HIS249
I	GLU330
I	ANP6009

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN I 1083

Chain	Residue
C	MSL5008
I	GLU131
I	GLU192
I	GLU199
I	MN1081
I	ANP6009

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN J 1091

Chain	Residue
J	GLU129
J	GLU199
J	ANP6010

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN J 1092

Chain	Residue
J	GLU129
J	HIS249
J	GLU330
J	ANP6010

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 1093

Chain	Residue
C	MSL5009
J	GLU131
J	GLU192
J	GLU199
J	ANP6010

site_id	DC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MSL C 5001

Chain	Residue
A	GLU131
A	TYR158
A	GLU192
A	GLY245
A	HIS249
A	ARG291
A	GLU297
A	THR298
A	ARG311
A	ARG332
A	MN1003
A	ANP6001
B	ASP56
C	HOH6010

site_id	DC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MSL C 5002

Chain	Residue
B	GLU131
B	GLU192
B	GLY245
B	GLY247
B	HIS249
B	ARG291
B	GLU297
B	THR298
B	ARG311
B	ARG332
B	MN1013
B	ANP6002
C	ASP56

site_id	DC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MSL C 5003

Chain	Residue
C	GLU131
C	GLU192
C	VAL193
C	ASN244
C	GLY245
C	GLY247
C	HIS249
C	ARG291
C	HIS296
C	GLU297
C	THR298
C	ARG311
C	ARG332
C	MN1023
C	ANP6003
E	ASP56

site_id	DC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MSL C 5004

Chain	Residue
A	ASP56
D	GLU131
D	TYR158
D	GLU192
D	ASN244
D	GLY245
D	GLY247
D	HIS249
D	ARG291
D	GLU297
D	THR298
D	ARG311
D	ARG332
D	MN1033
D	ANP6004
D	HOH6018

site_id	DC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MSL C 5005

Chain	Residue
D	ASP56
E	GLU131
E	GLU192
E	ASN244
E	GLY245
E	GLY247
E	HIS249
E	ARG291
E	GLU297
E	THR298
E	ARG311
E	ARG332
E	MN1043
E	ANP6005

site_id	DC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MSL C 5006

Chain	Residue
G	GLU131
G	GLU192
G	ASN244
G	GLY245
G	GLY247
G	HIS249
G	ARG291
G	HIS296
G	GLU297
G	THR298
G	ARG311
G	ARG332
G	MN1063
G	ANP6007
H	ASP56

site_id	EC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MSL C 5007

Chain	Residue
F	GLU131
F	GLU192
F	VAL193
F	ASN244
F	GLY245
F	GLY247
F	HIS249
F	ARG291
F	GLU297
F	ARG311
F	ARG332
F	MN1053
F	ANP6006
G	ASP56

site_id	EC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MSL C 5008

Chain	Residue
F	ASP56
I	GLU131
I	TYR158
I	GLU192
I	GLY245
I	HIS249
I	ARG291
I	GLU297
I	THR298
I	ARG311
I	ARG332
I	MN1083
I	ANP6009

site_id	EC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MSL C 5009

Chain	Residue
I	ASP56
J	GLU131
J	TYR158
J	GLU192
J	GLY245
J	HIS249
J	ARG291
J	GLU297
J	THR298
J	ARG311
J	ARG332
J	MN1093
J	ANP6010
J	HOH6041

site_id	EC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MSL C 5010

Chain	Residue
H	GLU131
H	TYR158
H	GLU192
H	GLY245
H	HIS249
H	ARG291
H	GLU297
H	ARG311
H	ARG332
H	MN1073
H	ANP6008
J	ASP56

site_id	EC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP A 6001

Chain	Residue
A	TRP125
A	GLY127
A	GLU129
A	SER187
A	GLU199
A	GLN201
A	GLY203
A	PRO204
A	HIS249
A	ASN251
A	TYR252
A	SER253
A	ARG311
A	ARG316
A	TYR328
A	GLU330
A	ARG332
A	MN1001
A	MN1002
A	MN1003
A	HOH6018
C	MSL5001

site_id	EC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ANP B 6002

Chain	Residue
B	TRP125
B	GLY127
B	GLU129
B	SER187
B	GLU199
B	GLN201
B	GLY203
B	PRO204
B	HIS249
B	ASN251
B	SER253
B	ARG311
B	ARG316
B	TYR328
B	GLU330
B	ARG332
B	MN1011
B	MN1012
B	MN1013
C	MSL5002

site_id	EC7
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP C 6003

Chain	Residue
C	TRP125
C	GLY127
C	GLU129
C	SER187
C	GLU199
C	GLN201
C	GLY203
C	PRO204
C	HIS249
C	ASN251
C	TYR252
C	SER253
C	ARG311
C	ARG316
C	TYR328
C	GLU330
C	ARG332
C	MN1021
C	MN1022
C	MN1023
C	MSL5003
C	HOH6004
C	HOH6037

site_id	EC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ANP D 6004

Chain	Residue
A	HOH6032
C	MSL5004
D	TRP125
D	GLY127
D	GLU129
D	SER187
D	GLU199
D	GLN201
D	GLY203
D	PRO204
D	HIS249
D	ASN251
D	TYR252
D	SER253
D	ARG311
D	ARG316
D	TYR328
D	GLU330
D	ARG332
D	MN1031
D	MN1032
D	MN1033
D	HOH6040

site_id	EC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ANP E 6005

Chain	Residue
C	MSL5005
E	TRP125
E	GLY127
E	GLU129
E	SER187
E	GLU192
E	GLU199
E	GLN201
E	GLY203
E	HIS249
E	ASN251
E	TYR252
E	SER253
E	ARG311
E	ARG316
E	TYR328
E	GLU330
E	ARG332
E	MN1041
E	MN1042
E	MN1043
E	HOH6010
E	HOH6039
E	HOH6045

site_id	FC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP F 6006

Chain	Residue
C	MSL5007
F	TRP125
F	GLY127
F	GLU129
F	SER187
F	GLU192
F	GLU199
F	GLN201
F	GLY203
F	HIS249
F	ASN251
F	TYR252
F	SER253
F	ARG311
F	ARG316
F	TYR328
F	GLU330
F	ARG332
F	MN1051
F	MN1052
F	MN1053
F	HOH6045

site_id	FC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ANP G 6007

Chain	Residue
C	MSL5006
G	TRP125
G	GLY127
G	GLU129
G	SER187
G	GLU199
G	GLN201
G	GLY203
G	PRO204
G	HIS249
G	ASN251
G	TYR252
G	SER253
G	ARG311
G	ARG316
G	TYR328
G	GLU330
G	ARG332
G	MN1061
G	MN1062
G	MN1063

site_id	FC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ANP H 6008

Chain	Residue
C	MSL5010
H	TRP125
H	GLY127
H	GLU129
H	SER187
H	GLU199
H	GLN201
H	GLY203
H	PRO204
H	ASN251
H	TYR252
H	SER253
H	ARG311
H	ARG316
H	TYR328
H	GLU330
H	ARG332
H	MN1071
H	MN1072
H	MN1073

site_id	FC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP I 6009

Chain	Residue
C	MSL5008
I	TRP125
I	GLY127
I	GLU129
I	SER187
I	GLU199
I	GLN201
I	GLY203
I	HIS249
I	ASN251
I	TYR252
I	SER253
I	ARG311
I	ARG316
I	TYR328
I	GLU330
I	ARG332
I	MN1081
I	MN1082
I	MN1083
I	HOH6015
I	HOH6040

site_id	FC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP J 6010

Chain	Residue
C	MSL5009
J	TRP125
J	GLY127
J	GLU129
J	SER187
J	GLU199
J	GLN201
J	GLY203
J	PRO204
J	HIS249
J	ASN251
J	TYR252
J	SER253
J	ARG311
J	ARG316
J	TYR328
J	GLU330
J	ARG332
J	MN1091
J	MN1092
J	MN1093
J	HOH6042

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. YDGSStgqapge.DSEviL

Chain	Residue	Details
A	TYR55-LEU72

site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgdw.NGAGaHtnyS

Chain	Residue	Details
A	LYS237-SER253

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
A	ARG311
A	ASP56
A	GLU297

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
J	ARG311
J	ASP56
J	GLU297

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
B	ARG311
B	ASP56
B	GLU297

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
C	ARG311
C	ASP56
C	GLU297

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
D	ARG311
D	ASP56
D	GLU297

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
E	ARG311
E	ASP56
E	GLU297

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
F	ARG311
F	ASP56
F	GLU297

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
G	ARG311
G	ASP56
G	GLU297

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
H	ARG311
H	ASP56
H	GLU297

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
I	ARG311
I	ASP56
I	GLU297

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)