Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2D3A

Crystal Structure of the Maize Glutamine Synthetase complexed with ADP and Methionine sulfoximine Phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006542	biological_process	glutamine biosynthetic process
A	0016874	molecular_function	ligase activity
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006542	biological_process	glutamine biosynthetic process
B	0016874	molecular_function	ligase activity
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006542	biological_process	glutamine biosynthetic process
C	0016874	molecular_function	ligase activity
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006542	biological_process	glutamine biosynthetic process
D	0016874	molecular_function	ligase activity
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006542	biological_process	glutamine biosynthetic process
E	0016874	molecular_function	ligase activity
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006542	biological_process	glutamine biosynthetic process
F	0016874	molecular_function	ligase activity
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006542	biological_process	glutamine biosynthetic process
G	0016874	molecular_function	ligase activity
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006542	biological_process	glutamine biosynthetic process
H	0016874	molecular_function	ligase activity
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006542	biological_process	glutamine biosynthetic process
I	0016874	molecular_function	ligase activity
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006542	biological_process	glutamine biosynthetic process
J	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1001

Chain	Residue
A	GLU129
A	GLU199
A	MN1003
A	P3S5001
A	ADP6001
A	HOH6015

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1002

Chain	Residue
A	ARG332
A	P3S5001
A	ADP6001
A	GLU129
A	HIS249
A	GLU330

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1003

Chain	Residue
A	GLU131
A	GLU192
A	GLU199
A	MN1001
A	P3S5001

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 1011

Chain	Residue
B	GLU129
B	GLU199
B	P3S5002
B	ADP6002

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 1012

Chain	Residue
B	GLU129
B	HIS249
B	GLU330
B	P3S5002
B	ADP6002

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 1013

Chain	Residue
B	GLU131
B	GLU192
B	GLU199
B	P3S5002
B	HOH6099

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 1021

Chain	Residue
C	GLU129
C	GLU199
C	P3S5003
C	ADP6003

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 1022

Chain	Residue
C	GLU129
C	HIS249
C	GLU330
C	P3S5003
C	ADP6003

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 1023

Chain	Residue
C	GLU131
C	GLU192
C	GLU199
C	P3S5003
C	HOH6010

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN D 1031

Chain	Residue
D	GLU129
D	GLU199
D	MN1032
D	MN1033
D	P3S5004
D	ADP6005
D	HOH6020

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 1032

Chain	Residue
D	GLU129
D	HIS249
D	GLU330
D	MN1031
D	P3S5004
D	ADP6005

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 1033

Chain	Residue
D	GLU131
D	GLU192
D	GLU199
D	MN1031
D	P3S5004

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 1041

Chain	Residue
E	GLU129
E	GLU199
E	P3S5005
E	ADP6004

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 1042

Chain	Residue
E	GLU129
E	HIS249
E	GLU330
E	ARG332
E	P3S5005
E	ADP6004

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 1043

Chain	Residue
E	GLU131
E	GLU192
E	GLU199
E	P3S5005
E	HOH6042

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 1051

Chain	Residue
F	GLU129
F	GLU199
F	MN1052
F	MN1053
F	P3S5007
F	ADP6007

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 1052

Chain	Residue
F	GLU129
F	HIS249
F	GLU330
F	MN1051
F	P3S5007
F	ADP6007

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 1053

Chain	Residue
F	GLU131
F	GLU192
F	GLU199
F	MN1051
F	P3S5007
F	HOH6017

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN G 1061

Chain	Residue
G	ADP6006
G	GLU129
G	GLU199
G	P3S5006

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 1062

Chain	Residue
G	GLU129
G	HIS249
G	GLU330
G	P3S5006
G	ADP6006

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 1063

Chain	Residue
G	GLU131
G	GLU192
G	GLU199
G	P3S5006
G	HOH6045

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 1071

Chain	Residue
H	GLU129
H	GLU199
H	MN1073
H	P3S5010
H	ADP6010

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 1072

Chain	Residue
H	GLU129
H	HIS249
H	GLU330
H	ARG332
H	P3S5010
H	ADP6010

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 1073

Chain	Residue
H	GLU131
H	GLU192
H	GLU199
H	MN1071
H	P3S5010

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 1081

Chain	Residue
I	GLU129
I	GLU199
I	MN1083
I	P3S5008
I	ADP6008

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 1082

Chain	Residue
I	GLU129
I	HIS249
I	GLU330
I	P3S5008
I	ADP6008

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 1083

Chain	Residue
I	GLU131
I	GLU192
I	GLU199
I	MN1081
I	P3S5008

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 1091

Chain	Residue
J	GLU129
J	GLU199
J	MN1093
J	P3S5009
J	ADP6009

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 1092

Chain	Residue
J	GLU129
J	HIS249
J	GLU330
J	P3S5009
J	ADP6009

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 1093

Chain	Residue
J	GLU131
J	GLU192
J	GLU199
J	MN1091
J	P3S5009

site_id	DC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S A 5001

Chain	Residue
A	GLU129
A	GLU131
A	GLU192
A	GLU199
A	GLY245
A	HIS249
A	ARG291
A	GLU297
A	THR298
A	ARG311
A	GLU330
A	ARG332
A	MN1001
A	MN1002
A	MN1003
A	ADP6001
A	HOH6010
A	HOH6011
A	HOH6063
B	ASP56

site_id	DC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S B 5002

Chain	Residue
B	GLU129
B	GLU131
B	GLU192
B	GLU199
B	GLY245
B	GLY247
B	HIS249
B	ARG291
B	GLU297
B	ARG311
B	GLU330
B	ARG332
B	MN1011
B	MN1012
B	MN1013
B	ADP6002
B	HOH6030
B	HOH6067
B	HOH6099
C	ASP56

site_id	DC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P3S C 5003

Chain	Residue
C	GLU129
C	GLU131
C	GLU192
C	GLU199
C	GLY245
C	HIS249
C	ARG291
C	GLU297
C	ARG311
C	GLU330
C	ARG332
C	MN1021
C	MN1022
C	MN1023
C	ADP6003
C	HOH6010
C	HOH6026
E	ASP56

site_id	DC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE P3S D 5004

Chain	Residue
A	ASP56
D	GLU129
D	GLU131
D	GLU192
D	GLU199
D	GLY245
D	ALA246
D	GLY247
D	HIS249
D	ARG291
D	GLU297
D	ARG311
D	GLU330
D	ARG332
D	MN1031
D	MN1032
D	MN1033
D	ADP6005
D	HOH6020
D	HOH6039
D	HOH6056
D	HOH6068

site_id	DC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE P3S E 5005

Chain	Residue
D	ASP56
E	GLU129
E	GLU131
E	GLU192
E	GLU199
E	GLY245
E	GLY247
E	HIS249
E	ARG291
E	GLU297
E	ARG311
E	GLU330
E	ARG332
E	MN1041
E	MN1042
E	MN1043
E	ADP6004

site_id	DC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S G 5006

Chain	Residue
G	GLU129
G	GLU131
G	GLU192
G	GLU199
G	GLY245
G	HIS249
G	ARG291
G	GLU297
G	THR298
G	ARG311
G	GLU330
G	ARG332
G	MN1061
G	MN1062
G	MN1063
G	ADP6006
G	HOH6028
G	HOH6045
G	HOH6047
H	ASP56

site_id	EC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE P3S F 5007

Chain	Residue
F	GLU129
F	GLU131
F	GLU192
F	GLU199
F	GLY245
F	GLY247
F	HIS249
F	ARG291
F	GLU297
F	ARG311
F	GLU330
F	ARG332
F	MN1051
F	MN1052
F	MN1053
F	ADP6007
F	HOH6014
F	HOH6017
F	HOH6021
F	HOH6065
G	ASP56

site_id	EC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE P3S I 5008

Chain	Residue
F	ASP56
I	GLU129
I	GLU131
I	GLU192
I	GLU199
I	ASN244
I	GLY245
I	HIS249
I	ARG291
I	GLU297
I	THR298
I	ARG311
I	GLU330
I	ARG332
I	MN1081
I	MN1082
I	MN1083
I	ADP6008
I	HOH6033
I	HOH6039

site_id	EC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE P3S J 5009

Chain	Residue
I	ASP56
J	GLU129
J	GLU131
J	GLU192
J	GLU199
J	ASN244
J	GLY245
J	HIS249
J	ARG291
J	GLU297
J	ARG311
J	GLU330
J	ARG332
J	MN1091
J	MN1092
J	MN1093
J	ADP6009
J	HOH6024
J	HOH6061

site_id	EC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE P3S H 5010

Chain	Residue
H	GLU129
H	GLU131
H	GLU192
H	GLU199
H	GLY245
H	HIS249
H	ARG291
H	GLU297
H	ARG311
H	GLU330
H	ARG332
H	MN1071
H	MN1072
H	MN1073
H	ADP6010
H	HOH6023
H	HOH6033
H	HOH6051
J	ASP56

site_id	EC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP A 6001

Chain	Residue
A	TRP125
A	GLY127
A	GLU129
A	SER187
A	GLU199
A	GLN201
A	GLY203
A	PRO204
A	ASN251
A	SER253
A	ARG311
A	ARG316
A	TYR328
A	GLU330
A	MN1001
A	MN1002
A	P3S5001
A	HOH6015
A	HOH6016
A	HOH6028
A	HOH6064

site_id	EC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP B 6002

Chain	Residue
B	TRP125
B	GLY127
B	GLU129
B	SER187
B	GLU199
B	GLN201
B	GLY203
B	PRO204
B	ASN251
B	SER253
B	ARG316
B	TYR328
B	GLU330
B	MN1011
B	MN1012
B	P3S5002
B	HOH6011
B	HOH6017
B	HOH6101

site_id	EC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP C 6003

Chain	Residue
C	TRP125
C	GLY127
C	GLU129
C	SER187
C	GLU199
C	GLN201
C	GLY203
C	PRO204
C	ASN251
C	TYR252
C	SER253
C	ARG311
C	ARG316
C	TYR328
C	GLU330
C	MN1021
C	MN1022
C	P3S5003
C	HOH6045
C	HOH6061

site_id	EC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP E 6004

Chain	Residue
D	HOH6058
E	TRP125
E	GLY127
E	GLU129
E	SER187
E	GLU199
E	GLN201
E	GLY203
E	PRO204
E	ASN251
E	SER253
E	ARG311
E	ARG316
E	TYR328
E	GLU330
E	MN1041
E	MN1042
E	P3S5005

site_id	EC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP D 6005

Chain	Residue
A	HOH6002
D	TRP125
D	GLY127
D	GLU129
D	SER187
D	GLU199
D	GLN201
D	VAL202
D	GLY203
D	PRO204
D	ASN251
D	SER253
D	ARG311
D	ARG316
D	TYR328
D	GLU330
D	MN1031
D	MN1032
D	P3S5004
D	HOH6020

site_id	FC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP G 6006

Chain	Residue
G	GLY127
G	GLU129
G	SER187
G	GLU199
G	GLN201
G	VAL202
G	GLY203
G	PRO204
G	ASN251
G	SER253
G	ARG311
G	ARG316
G	TYR328
G	GLU330
G	MN1061
G	MN1062
G	P3S5006
H	HOH6032

site_id	FC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP F 6007

Chain	Residue
F	TRP125
F	GLY127
F	GLU129
F	SER187
F	GLU199
F	GLN201
F	VAL202
F	GLY203
F	PRO204
F	ASN251
F	SER253
F	ARG311
F	ARG316
F	TYR328
F	GLU330
F	MN1051
F	MN1052
F	P3S5007
F	HOH6011
F	HOH6033
G	HOH6013
G	HOH6019

site_id	FC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP I 6008

Chain	Residue
I	TRP125
I	GLY127
I	GLU129
I	SER187
I	GLU199
I	GLN201
I	GLY203
I	PRO204
I	ASN251
I	SER253
I	ARG316
I	TYR328
I	GLU330
I	MN1081
I	MN1082
I	P3S5008
I	HOH6014
I	HOH6038
I	HOH6039
I	HOH6084

site_id	FC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP J 6009

Chain	Residue
J	TRP125
J	GLY127
J	GLU129
J	SER187
J	GLU199
J	GLN201
J	GLY203
J	PRO204
J	ASN251
J	SER253
J	ARG316
J	TYR328
J	GLU330
J	MN1091
J	MN1092
J	P3S5009
J	HOH6012
J	HOH6043
J	HOH6062
J	HOH6079

site_id	FC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP H 6010

Chain	Residue
H	TRP125
H	GLY127
H	GLU129
H	SER187
H	GLU199
H	GLN201
H	GLY203
H	PRO204
H	ASN251
H	SER253
H	ARG316
H	TYR328
H	GLU330
H	MN1071
H	MN1072
H	P3S5010
H	HOH6016
H	HOH6083
H	HOH6089
J	HOH6074

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. YDGSStgqapge.DSEviL

Chain	Residue	Details
A	TYR55-LEU72

site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgdw.NGAGaHtnyS

Chain	Residue	Details
A	LYS237-SER253

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	800
Details	Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
A	ARG311
A	ASP56
A	GLU297

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
J	ARG311
J	ASP56
J	GLU297

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
B	ARG311
B	ASP56
B	GLU297

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
C	ARG311
C	ASP56
C	GLU297

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
D	ARG311
D	ASP56
D	GLU297

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
E	ARG311
E	ASP56
E	GLU297

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
F	ARG311
F	ASP56
F	GLU297

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
G	ARG311
G	ASP56
G	GLU297

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
H	ARG311
H	ASP56
H	GLU297

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1hto

Chain	Residue	Details
I	ARG311
I	ASP56
I	GLU297

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)