2D33
Crystal Structure of gamma-Glutamylcysteine Synthetase Complexed with Aluminum Fluoride
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006750 | biological_process | glutathione biosynthetic process |
| A | 0006972 | biological_process | hyperosmotic response |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071243 | biological_process | cellular response to arsenic-containing substance |
| A | 0071288 | biological_process | cellular response to mercury ion |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006750 | biological_process | glutathione biosynthetic process |
| B | 0006972 | biological_process | hyperosmotic response |
| B | 0016874 | molecular_function | ligase activity |
| B | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071243 | biological_process | cellular response to arsenic-containing substance |
| B | 0071288 | biological_process | cellular response to mercury ion |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006750 | biological_process | glutathione biosynthetic process |
| C | 0006972 | biological_process | hyperosmotic response |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071243 | biological_process | cellular response to arsenic-containing substance |
| C | 0071288 | biological_process | cellular response to mercury ion |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004357 | molecular_function | glutamate-cysteine ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006750 | biological_process | glutathione biosynthetic process |
| D | 0006972 | biological_process | hyperosmotic response |
| D | 0016874 | molecular_function | ligase activity |
| D | 0016879 | molecular_function | ligase activity, forming carbon-nitrogen bonds |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071243 | biological_process | cellular response to arsenic-containing substance |
| D | 0071288 | biological_process | cellular response to mercury ion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 523 |
| Chain | Residue |
| A | GLU29 |
| A | ASP60 |
| A | GLU67 |
| A | GLU519 |
| A | AF3522 |
| A | MG525 |
| A | HOH700 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 524 |
| Chain | Residue |
| A | GLU328 |
| A | ADP521 |
| A | AF3522 |
| A | GLU27 |
| A | HIS150 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 525 |
| Chain | Residue |
| A | GLU27 |
| A | GLU67 |
| A | ADP521 |
| A | AF3522 |
| A | MG523 |
| A | HOH560 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 526 |
| Chain | Residue |
| A | ASN442 |
| A | ASP444 |
| A | HOH586 |
| A | HOH601 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1523 |
| Chain | Residue |
| B | GLU29 |
| B | ASP60 |
| B | GLU67 |
| B | GLU1519 |
| B | AF31522 |
| B | MG1525 |
| B | HOH1591 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1524 |
| Chain | Residue |
| B | GLU27 |
| B | HIS150 |
| B | GLU328 |
| B | ADP1521 |
| B | AF31522 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1525 |
| Chain | Residue |
| B | GLU27 |
| B | GLU67 |
| B | ADP1521 |
| B | AF31522 |
| B | MG1523 |
| B | HOH1589 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 2523 |
| Chain | Residue |
| C | GLU29 |
| C | ASP60 |
| C | GLU67 |
| C | GLU2519 |
| C | AF32522 |
| C | MG2525 |
| C | HOH2552 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2524 |
| Chain | Residue |
| C | GLU27 |
| C | HIS150 |
| C | GLU328 |
| C | ADP2521 |
| C | AF32522 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2525 |
| Chain | Residue |
| C | GLU27 |
| C | GLU67 |
| C | ADP2521 |
| C | AF32522 |
| C | MG2523 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 3523 |
| Chain | Residue |
| D | GLU29 |
| D | ASP60 |
| D | GLU67 |
| D | GLU3519 |
| D | AF33522 |
| D | HOH3593 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 3524 |
| Chain | Residue |
| D | GLU27 |
| D | HIS150 |
| D | GLU328 |
| D | ADP3521 |
| D | AF33522 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 3525 |
| Chain | Residue |
| D | GLU27 |
| D | GLU67 |
| D | ADP3521 |
| D | AF33522 |
| D | HOH3555 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLU A 519 |
| Chain | Residue |
| A | GLU29 |
| A | ASP60 |
| A | ILE146 |
| A | SER147 |
| A | HIS150 |
| A | ARG235 |
| A | ARG330 |
| A | CYS520 |
| A | AF3522 |
| A | MG523 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CYS A 520 |
| Chain | Residue |
| A | ASP60 |
| A | PHE61 |
| A | TYR131 |
| A | ASN297 |
| A | GLU519 |
| A | AF3522 |
| site_id | BC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE ADP A 521 |
| Chain | Residue |
| A | PHE153 |
| A | SER154 |
| A | LYS306 |
| A | GLU325 |
| A | TYR326 |
| A | GLU328 |
| A | AF3522 |
| A | MG524 |
| A | MG525 |
| A | HOH546 |
| A | HOH560 |
| A | HOH629 |
| A | HOH666 |
| A | GLN23 |
| A | GLY25 |
| A | LEU26 |
| A | GLU27 |
| A | GLU67 |
| A | ILE69 |
| A | THR70 |
| A | PRO71 |
| A | VAL72 |
| A | ASN152 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AF3 A 522 |
| Chain | Residue |
| A | GLU27 |
| A | ASP60 |
| A | GLU67 |
| A | HIS150 |
| A | ARG330 |
| A | GLU519 |
| A | CYS520 |
| A | ADP521 |
| A | MG523 |
| A | MG524 |
| A | MG525 |
| A | HOH560 |
| site_id | BC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GLU B 1519 |
| Chain | Residue |
| B | GLU29 |
| B | ASP60 |
| B | ILE146 |
| B | SER147 |
| B | GLY148 |
| B | HIS150 |
| B | ARG235 |
| B | TYR241 |
| B | ARG330 |
| B | CYS1520 |
| B | AF31522 |
| B | MG1523 |
| B | HOH1554 |
| B | HOH1582 |
| B | HOH1591 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CYS B 1520 |
| Chain | Residue |
| B | ASP60 |
| B | TYR131 |
| B | ARG132 |
| B | GLN144 |
| B | TYR241 |
| B | ASN297 |
| B | TYR300 |
| B | GLU1519 |
| site_id | CC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP B 1521 |
| Chain | Residue |
| B | GLN23 |
| B | GLY25 |
| B | LEU26 |
| B | GLU27 |
| B | GLU67 |
| B | ILE69 |
| B | THR70 |
| B | PRO71 |
| B | VAL72 |
| B | ASN152 |
| B | PHE153 |
| B | SER154 |
| B | LYS306 |
| B | VAL308 |
| B | GLU325 |
| B | TYR326 |
| B | GLU328 |
| B | AF31522 |
| B | MG1524 |
| B | MG1525 |
| B | HOH1541 |
| B | HOH1570 |
| site_id | CC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AF3 B 1522 |
| Chain | Residue |
| B | GLU27 |
| B | ASP60 |
| B | GLU67 |
| B | HIS150 |
| B | GLU328 |
| B | ARG330 |
| B | GLU1519 |
| B | ADP1521 |
| B | MG1523 |
| B | MG1524 |
| B | MG1525 |
| B | HOH1589 |
| B | HOH1591 |
| site_id | CC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU C 2519 |
| Chain | Residue |
| C | GLU29 |
| C | ASP60 |
| C | ILE146 |
| C | SER147 |
| C | GLY148 |
| C | HIS150 |
| C | ARG235 |
| C | TYR241 |
| C | ARG330 |
| C | CYS2520 |
| C | AF32522 |
| C | MG2523 |
| C | HOH2552 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CYS C 2520 |
| Chain | Residue |
| C | ASP60 |
| C | TYR131 |
| C | ARG132 |
| C | LEU135 |
| C | TYR241 |
| C | ASN297 |
| C | TYR300 |
| C | GLU2519 |
| C | AF32522 |
| site_id | CC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP C 2521 |
| Chain | Residue |
| C | GLN23 |
| C | GLY25 |
| C | LEU26 |
| C | GLU27 |
| C | GLU67 |
| C | ILE69 |
| C | THR70 |
| C | PRO71 |
| C | VAL72 |
| C | ASN152 |
| C | PHE153 |
| C | SER154 |
| C | LYS306 |
| C | GLU325 |
| C | TYR326 |
| C | GLU328 |
| C | AF32522 |
| C | MG2524 |
| C | MG2525 |
| C | HOH2528 |
| site_id | CC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AF3 C 2522 |
| Chain | Residue |
| C | GLU27 |
| C | ASP60 |
| C | GLU67 |
| C | HIS150 |
| C | ARG330 |
| C | GLU2519 |
| C | CYS2520 |
| C | ADP2521 |
| C | MG2523 |
| C | MG2524 |
| C | MG2525 |
| C | HOH2552 |
| site_id | CC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU D 3519 |
| Chain | Residue |
| D | GLU29 |
| D | ASP60 |
| D | ILE146 |
| D | SER147 |
| D | GLY148 |
| D | HIS150 |
| D | ARG235 |
| D | TYR241 |
| D | ARG330 |
| D | CYS3520 |
| D | AF33522 |
| D | MG3523 |
| D | HOH3593 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CYS D 3520 |
| Chain | Residue |
| D | ASP60 |
| D | TYR131 |
| D | TYR241 |
| D | ASN297 |
| D | TYR300 |
| D | GLU3519 |
| D | AF33522 |
| site_id | DC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP D 3521 |
| Chain | Residue |
| D | GLN23 |
| D | GLY25 |
| D | LEU26 |
| D | GLU27 |
| D | GLU67 |
| D | ILE69 |
| D | THR70 |
| D | PRO71 |
| D | VAL72 |
| D | ASN152 |
| D | SER154 |
| D | LYS306 |
| D | VAL308 |
| D | GLU325 |
| D | TYR326 |
| D | GLU328 |
| D | AF33522 |
| D | MG3524 |
| D | MG3525 |
| D | HOH3527 |
| D | HOH3538 |
| D | HOH3555 |
| site_id | DC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AF3 D 3522 |
| Chain | Residue |
| D | GLU27 |
| D | ASP60 |
| D | GLU67 |
| D | HIS150 |
| D | GLU3519 |
| D | CYS3520 |
| D | ADP3521 |
| D | MG3523 |
| D | MG3524 |
| D | MG3525 |
| D | HOH3555 |
| D | HOH3593 |
