Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2D2I

Crystal Structure of NADP-Dependent Glyceraldehyde-3-Phosphate Dehydrogenase from Synechococcus Sp. complexed with Nadp+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0048046	cellular_component	apoplast
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0048046	cellular_component	apoplast
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
O	0000166	molecular_function	nucleotide binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0048046	cellular_component	apoplast
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0000166	molecular_function	nucleotide binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0048046	cellular_component	apoplast
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0000166	molecular_function	nucleotide binding
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005829	cellular_component	cytosol
Q	0006006	biological_process	glucose metabolic process
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0048046	cellular_component	apoplast
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0000166	molecular_function	nucleotide binding
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005829	cellular_component	cytosol
R	0006006	biological_process	glucose metabolic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0048046	cellular_component	apoplast
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1339

Chain	Residue
A	SER154
A	THR213
A	GLY214
A	ALA215
A	HOH6376
A	HOH6410
A	HOH6478
A	HOH6805

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1340

Chain	Residue
A	ASP187
A	ARG200
A	ARG236
A	NAP1341
A	HOH6404
A	HOH6417
A	HOH6735
A	HOH6782
A	THR185

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 2339

Chain	Residue
B	SER154
B	THR213
B	GLY214
B	ALA215
B	HOH6409
B	HOH6711
B	HOH6815
B	HOH6825

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 2340

Chain	Residue
B	THR185
B	ASP187
B	ARG200
B	ARG236
B	NAP2341
B	HOH6525
B	HOH6731
B	HOH6750
B	HOH6804
B	HOH6826

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 O 3339

Chain	Residue
O	SER154
O	THR156
O	THR213
O	GLY214
O	ALA215
O	HOH6456
O	HOH6838

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 O 3340

Chain	Residue
O	THR185
O	ASP187
O	ARG200
O	ARG236
O	NAP3341
O	HOH6389

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 P 4339

Chain	Residue
P	SER154
P	THR213
P	GLY214
P	ALA215
P	HOH6600
P	HOH6717

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 P 4340

Chain	Residue
P	THR185
P	ASP187
P	ARG200
P	ARG236
P	NAP4341
P	HOH6395
P	HOH6653

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 5339

Chain	Residue
Q	SER154
Q	THR213
Q	GLY214
Q	ALA215
Q	HOH6486

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 Q 5340

Chain	Residue
Q	THR185
Q	ASP187
Q	ARG200
Q	ARG236
Q	NAP5341
Q	HOH6852

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 R 6339

Chain	Residue
R	SER154
R	THR213
R	GLY214
R	ALA215
R	HOH6737
R	HOH6832

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 R 6340

Chain	Residue
R	THR185
R	ASP187
R	ARG200
R	ARG236
R	NAP6341
R	HOH6497
R	HOH6858

site_id	BC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAP A 1341

Chain	Residue
A	THR122
A	ALA123
A	CYS155
A	LEU186
A	ASN318
A	TYR322
A	SO41340
A	HOH6397
A	HOH6417
A	HOH6436
A	HOH6513
A	HOH6598
A	HOH6797
A	HOH6802
B	SER194
B	HOH6545
B	HOH6599
A	GLY9
A	PHE10
A	GLY11
A	ARG12
A	ILE13
A	ASN35
A	ASN36
A	THR37
A	ASP79
A	ARG80
A	SER98
A	THR99
A	GLY100
A	VAL101

site_id	BC5
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP B 2341

Chain	Residue
A	SER194
B	GLY9
B	PHE10
B	GLY11
B	ARG12
B	ILE13
B	ASN36
B	THR37
B	ARG80
B	SER98
B	THR99
B	GLY100
B	THR122
B	ALA123
B	CYS155
B	LEU186
B	ASN318
B	GLU319
B	TYR322
B	SO42340
B	HOH6357
B	HOH6440
B	HOH6488
B	HOH6536
B	HOH6608
B	HOH6613
B	HOH6625
B	HOH6804
B	HOH6806

site_id	BC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAP O 3341

Chain	Residue
O	GLY9
O	PHE10
O	GLY11
O	ARG12
O	ILE13
O	THR37
O	ARG80
O	SER98
O	THR99
O	GLY100
O	THR122
O	ALA123
O	CYS155
O	THR185
O	LEU186
O	ASN318
O	TYR322
O	SO43340
O	HOH6515
O	HOH6540
O	HOH6562
O	HOH6660
O	HOH6719
O	HOH6749
O	HOH6836
R	SER194
R	HOH6833

site_id	BC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAP P 4341

Chain	Residue
P	GLY9
P	PHE10
P	GLY11
P	ARG12
P	ILE13
P	ASN35
P	THR37
P	ARG80
P	SER98
P	THR99
P	GLY100
P	THR122
P	ALA123
P	CYS155
P	LEU186
P	ASN318
P	GLU319
P	TYR322
P	SO44340
P	HOH6395
P	HOH6578
P	HOH6638
P	HOH6653
P	HOH6664
P	HOH6876
Q	SER194
Q	HOH6709

site_id	BC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP Q 5341

Chain	Residue
P	SER194
P	HOH6659
Q	GLY9
Q	PHE10
Q	GLY11
Q	ARG12
Q	ILE13
Q	ASN35
Q	THR37
Q	ARG80
Q	SER98
Q	THR99
Q	GLY100
Q	THR122
Q	ALA123
Q	CYS155
Q	LEU186
Q	ASN318
Q	GLU319
Q	TYR322
Q	SO45340
Q	HOH6457
Q	HOH6470
Q	HOH6552
Q	HOH6752

site_id	BC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAP R 6341

Chain	Residue
O	SER194
R	GLY9
R	GLY11
R	ARG12
R	ILE13
R	ASN35
R	THR37
R	ARG80
R	SER98
R	THR99
R	GLY100
R	VAL101
R	PHE102
R	THR122
R	ALA123
R	CYS155
R	LEU186
R	ASN318
R	GLU319
R	TYR322
R	SO46340
R	HOH6637
R	HOH6846

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA153-LEU160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)