2D2I
Crystal Structure of NADP-Dependent Glyceraldehyde-3-Phosphate Dehydrogenase from Synechococcus Sp. complexed with Nadp+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| O | 0006006 | biological_process | glucose metabolic process |
| O | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| O | 0050661 | molecular_function | NADP binding |
| O | 0051287 | molecular_function | NAD binding |
| P | 0006006 | biological_process | glucose metabolic process |
| P | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| P | 0050661 | molecular_function | NADP binding |
| P | 0051287 | molecular_function | NAD binding |
| Q | 0006006 | biological_process | glucose metabolic process |
| Q | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| Q | 0050661 | molecular_function | NADP binding |
| Q | 0051287 | molecular_function | NAD binding |
| R | 0006006 | biological_process | glucose metabolic process |
| R | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| R | 0050661 | molecular_function | NADP binding |
| R | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1339 |
| Chain | Residue |
| A | SER154 |
| A | THR213 |
| A | GLY214 |
| A | ALA215 |
| A | HOH6376 |
| A | HOH6410 |
| A | HOH6478 |
| A | HOH6805 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1340 |
| Chain | Residue |
| A | ASP187 |
| A | ARG200 |
| A | ARG236 |
| A | NAP1341 |
| A | HOH6404 |
| A | HOH6417 |
| A | HOH6735 |
| A | HOH6782 |
| A | THR185 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2339 |
| Chain | Residue |
| B | SER154 |
| B | THR213 |
| B | GLY214 |
| B | ALA215 |
| B | HOH6409 |
| B | HOH6711 |
| B | HOH6815 |
| B | HOH6825 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2340 |
| Chain | Residue |
| B | THR185 |
| B | ASP187 |
| B | ARG200 |
| B | ARG236 |
| B | NAP2341 |
| B | HOH6525 |
| B | HOH6731 |
| B | HOH6750 |
| B | HOH6804 |
| B | HOH6826 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 O 3339 |
| Chain | Residue |
| O | SER154 |
| O | THR156 |
| O | THR213 |
| O | GLY214 |
| O | ALA215 |
| O | HOH6456 |
| O | HOH6838 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 O 3340 |
| Chain | Residue |
| O | THR185 |
| O | ASP187 |
| O | ARG200 |
| O | ARG236 |
| O | NAP3341 |
| O | HOH6389 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 P 4339 |
| Chain | Residue |
| P | SER154 |
| P | THR213 |
| P | GLY214 |
| P | ALA215 |
| P | HOH6600 |
| P | HOH6717 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 P 4340 |
| Chain | Residue |
| P | THR185 |
| P | ASP187 |
| P | ARG200 |
| P | ARG236 |
| P | NAP4341 |
| P | HOH6395 |
| P | HOH6653 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 5339 |
| Chain | Residue |
| Q | SER154 |
| Q | THR213 |
| Q | GLY214 |
| Q | ALA215 |
| Q | HOH6486 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 Q 5340 |
| Chain | Residue |
| Q | THR185 |
| Q | ASP187 |
| Q | ARG200 |
| Q | ARG236 |
| Q | NAP5341 |
| Q | HOH6852 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 R 6339 |
| Chain | Residue |
| R | SER154 |
| R | THR213 |
| R | GLY214 |
| R | ALA215 |
| R | HOH6737 |
| R | HOH6832 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 R 6340 |
| Chain | Residue |
| R | THR185 |
| R | ASP187 |
| R | ARG200 |
| R | ARG236 |
| R | NAP6341 |
| R | HOH6497 |
| R | HOH6858 |
| site_id | BC4 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP A 1341 |
| Chain | Residue |
| A | THR122 |
| A | ALA123 |
| A | CYS155 |
| A | LEU186 |
| A | ASN318 |
| A | TYR322 |
| A | SO41340 |
| A | HOH6397 |
| A | HOH6417 |
| A | HOH6436 |
| A | HOH6513 |
| A | HOH6598 |
| A | HOH6797 |
| A | HOH6802 |
| B | SER194 |
| B | HOH6545 |
| B | HOH6599 |
| A | GLY9 |
| A | PHE10 |
| A | GLY11 |
| A | ARG12 |
| A | ILE13 |
| A | ASN35 |
| A | ASN36 |
| A | THR37 |
| A | ASP79 |
| A | ARG80 |
| A | SER98 |
| A | THR99 |
| A | GLY100 |
| A | VAL101 |
| site_id | BC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP B 2341 |
| Chain | Residue |
| A | SER194 |
| B | GLY9 |
| B | PHE10 |
| B | GLY11 |
| B | ARG12 |
| B | ILE13 |
| B | ASN36 |
| B | THR37 |
| B | ARG80 |
| B | SER98 |
| B | THR99 |
| B | GLY100 |
| B | THR122 |
| B | ALA123 |
| B | CYS155 |
| B | LEU186 |
| B | ASN318 |
| B | GLU319 |
| B | TYR322 |
| B | SO42340 |
| B | HOH6357 |
| B | HOH6440 |
| B | HOH6488 |
| B | HOH6536 |
| B | HOH6608 |
| B | HOH6613 |
| B | HOH6625 |
| B | HOH6804 |
| B | HOH6806 |
| site_id | BC6 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP O 3341 |
| Chain | Residue |
| O | GLY9 |
| O | PHE10 |
| O | GLY11 |
| O | ARG12 |
| O | ILE13 |
| O | THR37 |
| O | ARG80 |
| O | SER98 |
| O | THR99 |
| O | GLY100 |
| O | THR122 |
| O | ALA123 |
| O | CYS155 |
| O | THR185 |
| O | LEU186 |
| O | ASN318 |
| O | TYR322 |
| O | SO43340 |
| O | HOH6515 |
| O | HOH6540 |
| O | HOH6562 |
| O | HOH6660 |
| O | HOH6719 |
| O | HOH6749 |
| O | HOH6836 |
| R | SER194 |
| R | HOH6833 |
| site_id | BC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP P 4341 |
| Chain | Residue |
| P | GLY9 |
| P | PHE10 |
| P | GLY11 |
| P | ARG12 |
| P | ILE13 |
| P | ASN35 |
| P | THR37 |
| P | ARG80 |
| P | SER98 |
| P | THR99 |
| P | GLY100 |
| P | THR122 |
| P | ALA123 |
| P | CYS155 |
| P | LEU186 |
| P | ASN318 |
| P | GLU319 |
| P | TYR322 |
| P | SO44340 |
| P | HOH6395 |
| P | HOH6578 |
| P | HOH6638 |
| P | HOH6653 |
| P | HOH6664 |
| P | HOH6876 |
| Q | SER194 |
| Q | HOH6709 |
| site_id | BC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAP Q 5341 |
| Chain | Residue |
| P | SER194 |
| P | HOH6659 |
| Q | GLY9 |
| Q | PHE10 |
| Q | GLY11 |
| Q | ARG12 |
| Q | ILE13 |
| Q | ASN35 |
| Q | THR37 |
| Q | ARG80 |
| Q | SER98 |
| Q | THR99 |
| Q | GLY100 |
| Q | THR122 |
| Q | ALA123 |
| Q | CYS155 |
| Q | LEU186 |
| Q | ASN318 |
| Q | GLU319 |
| Q | TYR322 |
| Q | SO45340 |
| Q | HOH6457 |
| Q | HOH6470 |
| Q | HOH6552 |
| Q | HOH6752 |
| site_id | BC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAP R 6341 |
| Chain | Residue |
| O | SER194 |
| R | GLY9 |
| R | GLY11 |
| R | ARG12 |
| R | ILE13 |
| R | ASN35 |
| R | THR37 |
| R | ARG80 |
| R | SER98 |
| R | THR99 |
| R | GLY100 |
| R | VAL101 |
| R | PHE102 |
| R | THR122 |
| R | ALA123 |
| R | CYS155 |
| R | LEU186 |
| R | ASN318 |
| R | GLU319 |
| R | TYR322 |
| R | SO46340 |
| R | HOH6637 |
| R | HOH6846 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA153-LEU160 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| A | CYS155 | |
| A | HIS182 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| B | CYS155 | |
| B | HIS182 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| O | CYS155 | |
| O | HIS182 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| P | CYS155 | |
| P | HIS182 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| Q | CYS155 | |
| Q | HIS182 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1szj |
| Chain | Residue | Details |
| R | CYS155 | |
| R | HIS182 |
