2D1C
Crystal Structure Of TT0538 protein from Thermus thermophilus HB8
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
A | 0006097 | biological_process | glyoxylate cycle |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0006102 | biological_process | isocitrate metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
B | 0006097 | biological_process | glyoxylate cycle |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006102 | biological_process | isocitrate metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP A 1002 |
Chain | Residue |
A | LYS85 |
A | HIS280 |
A | GLY281 |
A | SER282 |
A | ALA283 |
A | LYS285 |
A | TYR286 |
A | ILE292 |
A | ASN293 |
A | ASP334 |
A | CIT1585 |
A | PRO87 |
A | HOH1618 |
A | HOH1717 |
A | HOH1800 |
A | HOH1810 |
A | HOH1839 |
A | HOH1975 |
B | ASN193 |
B | ILE222 |
B | ASN225 |
B | HIS228 |
A | LEU88 |
B | GLN229 |
B | LYS232 |
B | HOH1669 |
B | HOH1975 |
A | GLU89 |
A | THR90 |
A | ASN100 |
A | LEU261 |
A | GLU277 |
A | VAL279 |
site_id | AC2 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAP B 1003 |
Chain | Residue |
A | ASN193 |
A | ILE222 |
A | ASN225 |
A | GLN229 |
A | LYS232 |
A | HOH1625 |
A | HOH1759 |
B | LYS85 |
B | PRO87 |
B | LEU88 |
B | GLU89 |
B | THR90 |
B | ASN100 |
B | LEU261 |
B | GLU277 |
B | VAL279 |
B | HIS280 |
B | GLY281 |
B | SER282 |
B | ALA283 |
B | LYS285 |
B | TYR286 |
B | ILE292 |
B | ASN293 |
B | ASP334 |
B | CIT1586 |
B | HOH1612 |
B | HOH1687 |
B | HOH1711 |
B | HOH1745 |
B | HOH1816 |
B | HOH1840 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT A 1585 |
Chain | Residue |
A | THR90 |
A | SER98 |
A | ASN100 |
A | ARG104 |
A | ARG114 |
A | ARG137 |
A | TYR144 |
A | ASP248 |
A | NAP1002 |
B | LYS191 |
B | ASN193 |
B | ASP224 |
B | HOH1693 |
B | HOH1854 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CIT B 1586 |
Chain | Residue |
A | LYS191 |
A | ASN193 |
A | ASP224 |
B | THR90 |
B | SER98 |
B | ASN100 |
B | ARG104 |
B | ARG114 |
B | ARG137 |
B | TYR144 |
B | ASP248 |
B | NAP1003 |
B | HOH1688 |
B | HOH1698 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NMNGDIlSDltSgli.GGLGF |
Chain | Residue | Details |
A | ASN244-PHE263 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG104 | |
B | ASP224 | |
B | ASP248 | |
B | ASP252 | |
A | ARG114 | |
A | ARG137 | |
A | ASP224 | |
A | ASP248 | |
A | ASP252 | |
B | ARG104 | |
B | ARG114 | |
B | ARG137 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Critical for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | TYR144 | |
A | LYS191 | |
B | TYR144 | |
B | LYS191 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250 |
Chain | Residue | Details |
A | SER98 | |
B | SER98 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | ASP224 | |
A | LYS191 | |
B | TYR144 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | TYR144 | |
B | ASP224 | |
B | LYS191 |