Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2CNW

GDPALF4 complex of the SRP GTPases Ffh and FtsY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
A	0048500	cellular_component	signal recognition particle
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
B	0048500	cellular_component	signal recognition particle
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
C	0048500	cellular_component	signal recognition particle
D	0003924	molecular_function	GTPase activity
D	0005047	molecular_function	signal recognition particle binding
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006605	biological_process	protein targeting
D	0006612	biological_process	protein targeting to membrane
D	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
D	0016020	cellular_component	membrane
E	0003924	molecular_function	GTPase activity
E	0005047	molecular_function	signal recognition particle binding
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006605	biological_process	protein targeting
E	0006612	biological_process	protein targeting to membrane
E	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
E	0016020	cellular_component	membrane
F	0003924	molecular_function	GTPase activity
F	0005047	molecular_function	signal recognition particle binding
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006605	biological_process	protein targeting
F	0006612	biological_process	protein targeting to membrane
F	0006614	biological_process	SRP-dependent cotranslational protein targeting to membrane
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	THR112
A	GDP1001
A	ALF1007
A	HOH2038
A	HOH2058
A	HOH2085

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ALF A 1007

Chain	Residue
A	ASP135
A	ARG138
A	THR188
A	GLY190
A	GDP1001
A	MG1002
A	HOH2038
A	HOH2048
A	HOH2058
A	HOH2085
D	GDP1001
A	GLN107
A	GLY108
A	LYS111

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1002

Chain	Residue
B	THR112
B	GDP1001
B	ALF1007
B	HOH2027
B	HOH2046
B	HOH2064

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ALF B 1007

Chain	Residue
B	LEU106
B	GLN107
B	GLY108
B	LYS111
B	ASP135
B	ARG138
B	GLY190
B	GDP1001
B	MG1002
B	HOH2027
B	HOH2036
B	HOH2046
B	HOH2064
E	GDP1001

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 1002

Chain	Residue
C	THR112
C	GDP1001
C	ALF1007
C	HOH2053
C	HOH2082
C	HOH2117

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ALF C 1007

Chain	Residue
C	GLN107
C	GLY108
C	LYS111
C	ASP135
C	ARG138
C	THR188
C	GLY190
C	GDP1001
C	MG1002
C	HOH2053
C	HOH2054
C	HOH2082
C	HOH2117
F	GDP1001

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 1002

Chain	Residue
D	THR116
D	GDP1001
D	ALF1007
D	HOH2035
D	HOH2057
D	HOH2098

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ALF D 1007

Chain	Residue
A	GDP1001
D	ASN111
D	GLY112
D	LYS115
D	ASP139
D	ARG142
D	ALA193
D	GLY194
D	GDP1001
D	MG1002
D	HOH2033
D	HOH2035
D	HOH2057
D	HOH2098
D	HOH2099

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 1002

Chain	Residue
E	THR116
E	GDP1001
E	ALF1007
E	HOH2030
E	HOH2056
E	HOH2094

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ALF E 1007

Chain	Residue
E	HOH2056
E	HOH2094
B	GDP1001
B	HOH2040
E	ASN111
E	GLY112
E	LYS115
E	ASP139
E	ARG142
E	GLY194
E	GDP1001
E	MG1002
E	HOH2030
E	HOH2031

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 1002

Chain	Residue
F	THR116
F	GDP1001
F	ALF1007
F	HOH2027
F	HOH2046
F	HOH2071

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ALF F 1007

Chain	Residue
C	GDP1001
F	ASN111
F	GLY112
F	LYS115
F	ASP139
F	ARG142
F	GLY194
F	GDP1001
F	MG1002
F	HOH2027
F	HOH2028
F	HOH2046
F	HOH2069
F	HOH2071

site_id	BC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GDP A 1001

Chain	Residue
A	GLY108
A	SER109
A	GLY110
A	LYS111
A	THR112
A	THR113
A	LYS117
A	ARG138
A	GLN144
A	LYS246
A	ASP248
A	GLY271
A	VAL272
A	SER273
A	GLU274
A	MG1002
A	ALF1007
A	HOH2041
A	HOH2058
A	HOH2085
A	HOH2124
D	ASN111
D	GLY112
D	ARG142
D	LEU196
D	ALF1007

site_id	BC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GDP B 1001

Chain	Residue
B	GLY108
B	SER109
B	GLY110
B	LYS111
B	THR112
B	THR113
B	LYS117
B	ARG138
B	GLN144
B	LYS246
B	ASP248
B	GLY271
B	VAL272
B	SER273
B	GLU274
B	MG1002
B	ALF1007
B	HOH2046
B	HOH2064
B	HOH2094
B	HOH2104
E	ASN111
E	ARG142
E	LEU196
E	ALF1007

site_id	BC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GDP C 1001

Chain	Residue
C	GLY108
C	SER109
C	GLY110
C	LYS111
C	THR112
C	THR113
C	LYS117
C	ARG138
C	GLN144
C	LYS246
C	ASP248
C	GLY271
C	VAL272
C	SER273
C	GLU274
C	MG1002
C	ALF1007
C	HOH2045
C	HOH2082
C	HOH2117
C	HOH2118
F	ASN111
F	GLY112
F	ARG142
F	LEU196
F	ALF1007
F	HOH2018

site_id	BC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP D 1001

Chain	Residue
A	GLN107
A	ARG138
A	ALF1007
D	GLY112
D	VAL113
D	GLY114
D	LYS115
D	THR116
D	THR117
D	LYS121
D	GLN148
D	LYS256
D	ASP258
D	GLY281
D	VAL282
D	GLY283
D	GLU284
D	MG1002
D	ALF1007
D	HOH2025
D	HOH2057
D	HOH2098
D	HOH2099
D	HOH2100

site_id	BC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 5GP D 3001

Chain	Residue
A	SER164
A	SER167
A	GLU274
D	PHE141
D	ALA193
D	GLY194
D	LEU202
D	GLU205
D	HOH2064
D	HOH2101
D	HOH2102
D	HOH2103
D	HOH2104

site_id	BC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP E 1001

Chain	Residue
B	GLN107
B	ARG138
B	ALF1007
B	HOH2040
E	GLY112
E	VAL113
E	GLY114
E	LYS115
E	THR116
E	THR117
E	LYS121
E	GLN148
E	LYS256
E	ASP258
E	GLY281
E	VAL282
E	GLY283
E	GLU284
E	MG1002
E	ALF1007
E	HOH2022
E	HOH2056
E	HOH2094
E	HOH2095

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 5GP E 3001

Chain	Residue
B	SER164
B	SER167
B	ARG170
B	GLU274
B	LYS275
E	PHE141
E	ALA193
E	GLY194
E	LEU202
E	GLU205
E	HOH2096
E	HOH2097

site_id	CC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP F 1001

Chain	Residue
C	GLN107
C	ARG138
C	ALF1007
F	GLY112
F	VAL113
F	GLY114
F	LYS115
F	THR116
F	THR117
F	LYS121
F	GLN148
F	LYS256
F	ASP258
F	GLY281
F	VAL282
F	GLY283
F	GLU284
F	MG1002
F	ALF1007
F	HOH2020
F	HOH2046
F	HOH2069
F	HOH2070
F	HOH2071

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 5GP F 3001

Chain	Residue
C	SER164
C	SER167
C	ARG170
C	GLU274
C	LYS275
C	HOH2075
F	PHE141
F	ALA193
F	GLY194
F	LEU202
F	GLU205
F	HOH2073

Functional Information from PROSITE/UniProt

site_id	PS00300
Number of Residues	14
Details	SRP54 SRP54-type proteins GTP-binding domain signature. PIkFVGVGEgPddL

Chain	Residue	Details
D	PRO276-LEU289
A	PRO266-LEU279

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00306","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00920","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)