2CKI
Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 997 |
| Chain | Residue |
| A | TRP240 |
| A | GLU243 |
| A | PRO249 |
| A | GLN262 |
| A | ALA263 |
| A | HOH2243 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 998 |
| Chain | Residue |
| A | HOH2227 |
| A | HOH2231 |
| A | HOH2240 |
| A | HOH2241 |
| A | ASP254 |
| A | VAL256 |
| A | THR259 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | HIS228 |
| A | HIS232 |
| A | HIS238 |
| A | HOH2301 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1403 |
| Chain | Residue |
| A | ASP152 |
| A | HOH2139 |
| B | ASP152 |
| B | HOH2130 |
| B | HOH2132 |
| B | HOH2184 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 997 |
| Chain | Residue |
| B | TRP240 |
| B | GLU243 |
| B | PRO249 |
| B | GLN262 |
| B | ALA263 |
| B | HOH2216 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 998 |
| Chain | Residue |
| B | ASP254 |
| B | VAL256 |
| B | THR259 |
| B | HOH2219 |
| B | HOH2224 |
| B | HOH2234 |
| B | HOH2235 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 999 |
| Chain | Residue |
| B | HIS228 |
| B | HIS232 |
| B | HIS238 |
| B | HOH2289 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1404 |
| Chain | Residue |
| A | PRO68 |
| A | THR127 |
| A | LYS128 |
| A | ARG169 |
| A | TYR170 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1405 |
| Chain | Residue |
| A | ASP129 |
| A | PRO130 |
| A | TRP165 |
| A | HOH2108 |
| A | HOH2302 |
| A | HOH2303 |
| A | HOH2304 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1406 |
| Chain | Residue |
| A | TRP112 |
| A | ASN282 |
| A | HOH2268 |
| A | HOH2305 |
| B | GOL1404 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1403 |
| Chain | Residue |
| B | ASP129 |
| B | PRO130 |
| B | TRP165 |
| B | HOH2095 |
| B | HOH2290 |
| B | HOH2292 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1404 |
| Chain | Residue |
| A | GOL1406 |
| B | TRP112 |
| B | ASN282 |
| B | HOH2232 |
| B | HOH2259 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1405 |
| Chain | Residue |
| B | PRO68 |
| B | THR127 |
| B | LYS128 |
| B | ARG169 |
| B | TYR170 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | Binding site for Di-peptide ARG A 401 and VAL A 402 |
| Chain | Residue |
| A | GLN185 |
| A | ILE187 |
| A | LEU188 |
| A | GLY189 |
| A | PHE220 |
| A | THR225 |
| A | GLU229 |
| A | VAL293 |
| A | ASP295 |
| A | HOH2299 |
| A | HOH2300 |
| A | HOH2301 |
| site_id | BC6 |
| Number of Residues | 14 |
| Details | Binding site for Di-peptide ARG B 401 and VAL B 402 |
| Chain | Residue |
| B | GLN185 |
| B | ILE187 |
| B | LEU188 |
| B | GLY189 |
| B | PHE220 |
| B | ARG224 |
| B | THR225 |
| B | GLU229 |
| B | TYR292 |
| B | VAL293 |
| B | ASP295 |
| B | HOH2287 |
| B | HOH2288 |
| B | HOH2289 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TATHEIGHWL |
| Chain | Residue | Details |
| A | THR225-LEU234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16627477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17097044","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16627477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16627477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17097044","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16627477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17097044","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
