2CH5

Crystal structure of human N-acetylglucosamine kinase in complex with N-acetylglucosamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006046	biological_process	N-acetylglucosamine catabolic process
A	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
A	0006051	biological_process	N-acetylmannosamine metabolic process
A	0009384	molecular_function	N-acylmannosamine kinase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0032495	biological_process	response to muramyl dipeptide
A	0042742	biological_process	defense response to bacterium
A	0045127	molecular_function	N-acetylglucosamine kinase activity
A	0070062	cellular_component	extracellular exosome
A	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
A	0160047	molecular_function	muramyl dipeptide kinase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006046	biological_process	N-acetylglucosamine catabolic process
B	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
B	0006051	biological_process	N-acetylmannosamine metabolic process
B	0009384	molecular_function	N-acylmannosamine kinase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0032495	biological_process	response to muramyl dipeptide
B	0042742	biological_process	defense response to bacterium
B	0045127	molecular_function	N-acetylglucosamine kinase activity
B	0070062	cellular_component	extracellular exosome
B	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
B	0160047	molecular_function	muramyl dipeptide kinase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006044	biological_process	N-acetylglucosamine metabolic process
C	0006046	biological_process	N-acetylglucosamine catabolic process
C	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
C	0006051	biological_process	N-acetylmannosamine metabolic process
C	0009384	molecular_function	N-acylmannosamine kinase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0032495	biological_process	response to muramyl dipeptide
C	0042742	biological_process	defense response to bacterium
C	0045127	molecular_function	N-acetylglucosamine kinase activity
C	0070062	cellular_component	extracellular exosome
C	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
C	0160047	molecular_function	muramyl dipeptide kinase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006044	biological_process	N-acetylglucosamine metabolic process
D	0006046	biological_process	N-acetylglucosamine catabolic process
D	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
D	0006051	biological_process	N-acetylmannosamine metabolic process
D	0009384	molecular_function	N-acylmannosamine kinase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0032495	biological_process	response to muramyl dipeptide
D	0042742	biological_process	defense response to bacterium
D	0045127	molecular_function	N-acetylglucosamine kinase activity
D	0070062	cellular_component	extracellular exosome
D	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
D	0160047	molecular_function	muramyl dipeptide kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17010375","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2CH6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17010375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CH5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"12112843","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---