2CG8
The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006760 | biological_process | folic acid-containing compound metabolic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006760 | biological_process | folic acid-containing compound metabolic process |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| C | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006760 | biological_process | folic acid-containing compound metabolic process |
| C | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046656 | biological_process | folic acid biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| D | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006760 | biological_process | folic acid-containing compound metabolic process |
| D | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046656 | biological_process | folic acid biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. HwGPRliDLDLL |
| Chain | Residue | Details |
| A | HIS205-LEU216 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor/acceptor; for DHNA activity => ECO:0000250|UniProtKB:P0AC16 |
| Chain | Residue | Details |
| A | LYS99 | |
| B | LYS99 | |
| C | LYS99 | |
| D | LYS99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0AC16 |
| Chain | Residue | Details |
| A | GLU21 | |
| D | GLU21 | |
| D | TYR53 | |
| D | ILE72 | |
| A | TYR53 | |
| A | ILE72 | |
| B | GLU21 | |
| B | TYR53 | |
| B | ILE72 | |
| C | GLU21 | |
| C | TYR53 | |
| C | ILE72 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P26281 |
| Chain | Residue | Details |
| A | THR160 | |
| B | PHE171 | |
| B | LEU192 | |
| B | ARG200 | |
| B | ASP212 | |
| B | ASP214 | |
| B | ASP227 | |
| B | ARG238 | |
| C | THR160 | |
| C | PHE171 | |
| C | LEU192 | |
| A | PHE171 | |
| C | ARG200 | |
| C | ASP212 | |
| C | ASP214 | |
| C | ASP227 | |
| C | ARG238 | |
| D | THR160 | |
| D | PHE171 | |
| D | LEU192 | |
| D | ARG200 | |
| D | ASP212 | |
| A | LEU192 | |
| D | ASP214 | |
| D | ASP227 | |
| D | ARG238 | |
| A | ARG200 | |
| A | ASP212 | |
| A | ASP214 | |
| A | ASP227 | |
| A | ARG238 | |
| B | THR160 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG200 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | ARG209 | |
| B | ARG200 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| C | ARG200 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| D | ARG209 | |
| D | ARG200 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | GLU21 | |
| A | LYS99 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | GLU21 | |
| B | LYS99 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| C | GLU21 | |
| C | LYS99 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| D | GLU21 | |
| D | LYS99 |
