2CG8
The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| A | 0006760 | biological_process | folic acid-containing compound metabolic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| B | 0006760 | biological_process | folic acid-containing compound metabolic process |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| C | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| C | 0006760 | biological_process | folic acid-containing compound metabolic process |
| C | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| D | 0004150 | molecular_function | dihydroneopterin aldolase activity |
| D | 0006760 | biological_process | folic acid-containing compound metabolic process |
| D | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. HwGPRliDLDLL |
| Chain | Residue | Details |
| A | HIS205-LEU216 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor; for DHNA activity","evidences":[{"source":"UniProtKB","id":"P0AC16","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0AC16","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P26281","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 118 |
| Details | Region: {"description":"DHNA"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG200 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | ARG209 | |
| B | ARG200 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| C | ARG200 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| D | ARG209 | |
| D | ARG200 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | GLU21 | |
| A | LYS99 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | GLU21 | |
| B | LYS99 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| C | GLU21 | |
| C | LYS99 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| D | GLU21 | |
| D | LYS99 |
