2CG8

The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A	0004150	molecular_function	dihydroneopterin aldolase activity
A	0005524	molecular_function	ATP binding
A	0006760	biological_process	folic acid-containing compound metabolic process
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046656	biological_process	folic acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
B	0004150	molecular_function	dihydroneopterin aldolase activity
B	0005524	molecular_function	ATP binding
B	0006760	biological_process	folic acid-containing compound metabolic process
B	0009396	biological_process	folic acid-containing compound biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046656	biological_process	folic acid biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
C	0004150	molecular_function	dihydroneopterin aldolase activity
C	0005524	molecular_function	ATP binding
C	0006760	biological_process	folic acid-containing compound metabolic process
C	0009396	biological_process	folic acid-containing compound biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046656	biological_process	folic acid biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0003848	molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
D	0004150	molecular_function	dihydroneopterin aldolase activity
D	0005524	molecular_function	ATP binding
D	0006760	biological_process	folic acid-containing compound metabolic process
D	0009396	biological_process	folic acid-containing compound biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046656	biological_process	folic acid biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00794
Number of Residues	12
Details	HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. HwGPRliDLDLL

Chain	Residue	Details
A	HIS205-LEU216

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor; for DHNA activity","evidences":[{"source":"UniProtKB","id":"P0AC16","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0AC16","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	118
Details	Region: {"description":"DHNA"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
A	ARG200

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
B	ARG209
B	ARG200

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
C	ARG200

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
D	ARG209
D	ARG200

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
A	GLU21
A	LYS99

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
B	GLU21
B	LYS99

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
C	GLU21
C	LYS99

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1hka

Chain	Residue	Details
D	GLU21
D	LYS99

---