2CFM
ATP-DEPENDENT DNA LIGASE FROM PYROCOCCUS FURIOSUS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003909 | molecular_function | DNA ligase activity |
| A | 0003910 | molecular_function | DNA ligase (ATP) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006273 | biological_process | lagging strand elongation |
| A | 0006281 | biological_process | DNA repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A1562 |
| Chain | Residue |
| A | GLU299 |
| A | HOH2218 |
| A | HOH2253 |
| A | HOH2329 |
| A | HOH2330 |
| A | HOH2419 |
| A | HOH2450 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMP A1563 |
| Chain | Residue |
| A | GLU247 |
| A | ILE248 |
| A | LYS249 |
| A | TYR250 |
| A | ARG254 |
| A | ARG269 |
| A | GLU299 |
| A | PHE339 |
| A | MSE401 |
| A | LYS403 |
| A | LYS420 |
| A | HOH2233 |
| A | HOH2253 |
| A | HOH2356 |
| A | HOH2447 |
| A | HOH2448 |
| A | HOH2449 |
| A | HOH2450 |
| A | LEU226 |
| A | ALA227 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00407","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16820169","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00407","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16820169","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CFM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a0i |
| Chain | Residue | Details |
| A | LYS249 |
