2CFA
Structure of viral flavin-dependant thymidylate synthase ThyX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE FAD A 1219 |
| Chain | Residue |
| A | TRP54 |
| A | HIS177 |
| A | ARG182 |
| A | HOH2047 |
| A | HOH2062 |
| A | HOH2098 |
| A | HOH2099 |
| A | HOH2100 |
| A | HOH2101 |
| A | HOH2102 |
| A | HOH2103 |
| A | ARG78 |
| A | HOH2104 |
| A | HOH2105 |
| A | HOH2106 |
| B | HIS51 |
| B | HIS53 |
| B | TRP54 |
| B | SER55 |
| B | ARG173 |
| B | FAD1217 |
| A | HIS79 |
| A | ARG80 |
| A | SER81 |
| A | GLN85 |
| A | GLU86 |
| A | ARG173 |
| A | ASP174 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FAD B 1217 |
| Chain | Residue |
| A | CME48 |
| A | HIS51 |
| A | HIS53 |
| A | TRP54 |
| A | SER55 |
| A | ARG173 |
| A | FAD1219 |
| A | HOH2029 |
| A | HOH2033 |
| A | HOH2035 |
| B | TRP54 |
| B | ARG78 |
| B | HIS79 |
| B | ARG80 |
| B | SER81 |
| B | GLN85 |
| B | GLU86 |
| B | ARG173 |
| B | ASP174 |
| B | HIS177 |
| B | ARG182 |
| B | HOH2054 |
| B | HOH2073 |
| B | HOH2074 |
| B | HOH2075 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000250|UniProtKB:Q9WYT0 |
| Chain | Residue | Details |
| B | ARG182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9WYT0 |
| Chain | Residue | Details |
| B | SER55 | |
| B | GLN75 | |
| B | ARG78 | |
| B | GLU86 | |
| B | HIS177 | |
| B | ARG182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:Q9WYT0 |
| Chain | Residue | Details |
| B | ARG155 |
