2CDN
Crystal structure of Mycobacterium tuberculosis adenylate kinase complexed with two molecules of ADP and Mg
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004017 | molecular_function | adenylate kinase activity |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0009123 | biological_process | nucleoside monophosphate metabolic process |
| A | 0009132 | biological_process | nucleoside diphosphate metabolic process |
| A | 0009141 | biological_process | nucleoside triphosphate metabolic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| A | 0044209 | biological_process | AMP salvage |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| A | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 200 |
| Chain | Residue |
| A | ADP201 |
| A | ADP202 |
| A | HOH2062 |
| A | HOH2126 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP A 201 |
| Chain | Residue |
| A | ASP57 |
| A | LEU58 |
| A | VAL59 |
| A | THR64 |
| A | GLY85 |
| A | TYR86 |
| A | ARG88 |
| A | GLN92 |
| A | ARG127 |
| A | ARG129 |
| A | ARG140 |
| A | MG200 |
| A | ADP202 |
| A | HOH2062 |
| A | HOH2091 |
| A | HOH2125 |
| A | HOH2126 |
| A | HOH2127 |
| A | HOH2128 |
| A | LYS13 |
| A | THR31 |
| A | GLY32 |
| A | ARG36 |
| A | LEU53 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ADP A 202 |
| Chain | Residue |
| A | GLY10 |
| A | ALA11 |
| A | GLY12 |
| A | LYS13 |
| A | GLY14 |
| A | THR15 |
| A | ARG123 |
| A | ARG127 |
| A | GLY166 |
| A | THR167 |
| A | MET168 |
| A | MG200 |
| A | ADP201 |
| A | HOH2014 |
| A | HOH2062 |
| A | HOH2083 |
| A | HOH2129 |
| A | HOH2130 |
| A | HOH2131 |
| A | HOH2132 |
| A | HOH2133 |
| A | HOH2134 |
Functional Information from PROSITE/UniProt
| site_id | PS00113 |
| Number of Residues | 12 |
| Details | ADENYLATE_KINASE Adenylate kinase signature. FILDGYPRsveQ |
| Chain | Residue | Details |
| A | PHE81-GLN92 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00235, ECO:0000269|PubMed:16672241 |
| Chain | Residue | Details |
| A | GLY10 | |
| A | GLY166 | |
| A | THR31 | |
| A | ARG36 | |
| A | ASP57 | |
| A | GLY85 | |
| A | GLN92 | |
| A | ARG127 | |
| A | ARG129 | |
| A | ARG140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036 |
| Chain | Residue | Details |
| A | LYS94 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1zio |
| Chain | Residue | Details |
| A | LYS13 | |
| A | ARG140 | |
| A | ASP131 | |
| A | ARG129 | |
| A | ARG127 | |
| A | ASP132 |
