2CDN

Crystal structure of Mycobacterium tuberculosis adenylate kinase complexed with two molecules of ADP and Mg

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004017	molecular_function	AMP kinase activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006144	biological_process	purine nucleobase metabolic process
A	0009123	biological_process	nucleoside monophosphate metabolic process
A	0009132	biological_process	nucleoside diphosphate metabolic process
A	0009141	biological_process	nucleoside triphosphate metabolic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019205	molecular_function	nucleobase-containing compound kinase activity
A	0044209	biological_process	AMP salvage
A	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 200

Chain	Residue
A	ADP201
A	ADP202
A	HOH2062
A	HOH2126

---

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ADP A 201

Chain	Residue
A	ASP57
A	LEU58
A	VAL59
A	THR64
A	GLY85
A	TYR86
A	ARG88
A	GLN92
A	ARG127
A	ARG129
A	ARG140
A	MG200
A	ADP202
A	HOH2062
A	HOH2091
A	HOH2125
A	HOH2126
A	HOH2127
A	HOH2128
A	LYS13
A	THR31
A	GLY32
A	ARG36
A	LEU53

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 202

Chain	Residue
A	GLY10
A	ALA11
A	GLY12
A	LYS13
A	GLY14
A	THR15
A	ARG123
A	ARG127
A	GLY166
A	THR167
A	MET168
A	MG200
A	ADP201
A	HOH2014
A	HOH2062
A	HOH2083
A	HOH2129
A	HOH2130
A	HOH2131
A	HOH2132
A	HOH2133
A	HOH2134

---

Functional Information from PROSITE/UniProt

site_id	PS00113
Number of Residues	12
Details	ADENYLATE_KINASE Adenylate kinase signature. FILDGYPRsveQ

Chain	Residue	Details
A	PHE81-GLN92

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	29
Details	Region: {"description":"NMP","evidences":[{"source":"HAMAP-Rule","id":"MF_00235","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14705932","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"LID","evidences":[{"source":"HAMAP-Rule","id":"MF_00235","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14705932","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00235","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16672241","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20066036","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1zio

Chain	Residue	Details
A	LYS13
A	ARG140
A	ASP131
A	ARG129
A	ARG127
A	ASP132

---