2CDH
ARCHITECTURE OF THE THERMOMYCES LANUGINOSUS FUNGAL FATTY ACID SYNTHASE AT 5 ANGSTROM RESOLUTION.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 0 | 0010181 | molecular_function | FMN binding |
| 0 | 0016491 | molecular_function | oxidoreductase activity |
| 1 | 0010181 | molecular_function | FMN binding |
| 1 | 0016491 | molecular_function | oxidoreductase activity |
| 2 | 0010181 | molecular_function | FMN binding |
| 2 | 0016491 | molecular_function | oxidoreductase activity |
| 3 | 0010181 | molecular_function | FMN binding |
| 3 | 0016491 | molecular_function | oxidoreductase activity |
| 4 | 0016740 | molecular_function | transferase activity |
| 5 | 0016740 | molecular_function | transferase activity |
| 6 | 0016740 | molecular_function | transferase activity |
| 7 | 0016740 | molecular_function | transferase activity |
| 8 | 0016740 | molecular_function | transferase activity |
| 9 | 0016740 | molecular_function | transferase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| C | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0044281 | biological_process | small molecule metabolic process |
| C | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| D | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0044281 | biological_process | small molecule metabolic process |
| D | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| E | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0044281 | biological_process | small molecule metabolic process |
| E | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| F | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0016746 | molecular_function | acyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0044281 | biological_process | small molecule metabolic process |
| F | 1903966 | biological_process | monounsaturated fatty acid biosynthetic process |
| G | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0051287 | molecular_function | NAD binding |
| H | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0051287 | molecular_function | NAD binding |
| I | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| I | 0006633 | biological_process | fatty acid biosynthetic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0051287 | molecular_function | NAD binding |
| J | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0051287 | molecular_function | NAD binding |
| K | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| K | 0006633 | biological_process | fatty acid biosynthetic process |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0051287 | molecular_function | NAD binding |
| L | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0051287 | molecular_function | NAD binding |
| M | 0016740 | molecular_function | transferase activity |
| N | 0016740 | molecular_function | transferase activity |
| O | 0016740 | molecular_function | transferase activity |
| P | 0016740 | molecular_function | transferase activity |
| Q | 0016740 | molecular_function | transferase activity |
| R | 0016740 | molecular_function | transferase activity |
| Y | 0010181 | molecular_function | FMN binding |
| Y | 0016491 | molecular_function | oxidoreductase activity |
| Z | 0010181 | molecular_function | FMN binding |
| Z | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvglignigQanYAAAKAGViGFSkTAA |
| Chain | Residue | Details |
| G | SER154-ALA182 |
| site_id | PS00557 |
| Number of Residues | 7 |
| Details | FMN_HYDROXY_ACID_DH_1 FMN-dependent alpha-hydroxy acid dehydrogenases active site. SNHGARQ |
| Chain | Residue | Details |
| 0 | SER252-GLN258 |
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GVNysISsACATSahCI |
| Chain | Residue | Details |
| A | GLY154-ILE170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| G | TYR167 | |
| H | TYR167 | |
| I | TYR167 | |
| J | TYR167 | |
| K | TYR167 | |
| L | TYR167 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| G | VAL22 | |
| E | HIS333 | |
| F | HIS298 | |
| F | HIS333 | |
| H | VAL22 | |
| I | VAL22 | |
| J | VAL22 | |
| K | VAL22 | |
| L | VAL22 | |
| D | HIS298 | |
| D | HIS333 | |
| E | HIS298 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| G | SER154 | |
| H | SER154 | |
| I | SER154 | |
| J | SER154 | |
| K | SER154 | |
| L | SER154 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | PHE392 | |
| A | HIS298 | |
| A | HIS333 | |
| A | CYS163 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 7 | SER97 | |
| 7 | HIS201 | |
| 7 | GLN250 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 8 | SER97 | |
| 8 | HIS201 | |
| 8 | GLN250 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 9 | SER97 | |
| 9 | HIS201 | |
| 9 | GLN250 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| M | SER97 | |
| M | HIS201 | |
| M | GLN250 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| N | SER97 | |
| N | HIS201 | |
| N | GLN250 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| O | SER97 | |
| O | HIS201 | |
| O | GLN250 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| P | SER97 | |
| P | HIS201 | |
| P | GLN250 |
| site_id | CSA17 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| Q | SER97 | |
| Q | HIS201 | |
| Q | GLN250 |
| site_id | CSA18 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| R | SER97 | |
| R | HIS201 | |
| R | GLN250 |
| site_id | CSA19 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | PHE392 | |
| A | LYS328 | |
| A | HIS298 | |
| A | HIS333 | |
| A | PHE390 | |
| A | CYS163 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | PHE392 | |
| B | HIS298 | |
| B | HIS333 | |
| B | CYS163 |
| site_id | CSA20 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | PHE392 | |
| B | LYS328 | |
| B | HIS298 | |
| B | HIS333 | |
| B | PHE390 | |
| B | CYS163 |
| site_id | CSA21 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| C | PHE392 | |
| C | LYS328 | |
| C | HIS298 | |
| C | HIS333 | |
| C | PHE390 | |
| C | CYS163 |
| site_id | CSA22 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| D | PHE392 | |
| D | LYS328 | |
| D | HIS298 | |
| D | HIS333 | |
| D | PHE390 | |
| D | CYS163 |
| site_id | CSA23 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| E | PHE392 | |
| E | LYS328 | |
| E | HIS298 | |
| E | HIS333 | |
| E | PHE390 | |
| E | CYS163 |
| site_id | CSA24 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| F | PHE392 | |
| F | LYS328 | |
| F | HIS298 | |
| F | HIS333 | |
| F | PHE390 | |
| F | CYS163 |
| site_id | CSA25 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| S | GLY216 | |
| S | ASP193 | |
| S | HIS198 | |
| S | ILE213 |
| site_id | CSA26 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| T | GLY216 | |
| T | ASP193 | |
| T | HIS198 | |
| T | ILE213 |
| site_id | CSA27 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| U | GLY216 | |
| U | ASP193 | |
| U | HIS198 | |
| U | ILE213 |
| site_id | CSA28 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| V | GLY216 | |
| V | ASP193 | |
| V | HIS198 | |
| V | ILE213 |
| site_id | CSA29 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| W | GLY216 | |
| W | ASP193 | |
| W | HIS198 | |
| W | ILE213 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| C | PHE392 | |
| C | HIS298 | |
| C | HIS333 | |
| C | CYS163 |
| site_id | CSA30 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| X | GLY216 | |
| X | ASP193 | |
| X | HIS198 | |
| X | ILE213 |
| site_id | CSA31 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| G | ASN126 | |
| G | SER154 | |
| G | TYR167 | |
| G | LYS171 |
| site_id | CSA32 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| H | ASN126 | |
| H | SER154 | |
| H | TYR167 | |
| H | LYS171 |
| site_id | CSA33 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| I | ASN126 | |
| I | SER154 | |
| I | TYR167 | |
| I | LYS171 |
| site_id | CSA34 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| J | ASN126 | |
| J | SER154 | |
| J | TYR167 | |
| J | LYS171 |
| site_id | CSA35 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| K | ASN126 | |
| K | SER154 | |
| K | TYR167 | |
| K | LYS171 |
| site_id | CSA36 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| L | ASN126 | |
| L | SER154 | |
| L | TYR167 | |
| L | LYS171 |
| site_id | CSA37 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| G | GLN164 | |
| G | LYS171 |
| site_id | CSA38 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| H | GLN164 | |
| H | LYS171 |
| site_id | CSA39 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| I | GLN164 | |
| I | LYS171 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| D | PHE392 | |
| D | HIS298 | |
| D | HIS333 | |
| D | CYS163 |
| site_id | CSA40 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| J | GLN164 | |
| J | LYS171 |
| site_id | CSA41 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| K | GLN164 | |
| K | LYS171 |
| site_id | CSA42 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| L | GLN164 | |
| L | LYS171 |
| site_id | CSA43 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| G | TYR167 | |
| G | LYS171 |
| site_id | CSA44 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| H | TYR167 | |
| H | LYS171 |
| site_id | CSA45 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| I | TYR167 | |
| I | LYS171 |
| site_id | CSA46 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| J | TYR167 | |
| J | LYS171 |
| site_id | CSA47 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| K | TYR167 | |
| K | LYS171 |
| site_id | CSA48 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| L | TYR167 | |
| L | LYS171 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| E | PHE392 | |
| E | HIS298 | |
| E | HIS333 | |
| E | CYS163 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| F | PHE392 | |
| F | HIS298 | |
| F | HIS333 | |
| F | CYS163 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 4 | SER97 | |
| 4 | HIS201 | |
| 4 | GLN250 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 5 | SER97 | |
| 5 | HIS201 | |
| 5 | GLN250 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| 6 | SER97 | |
| 6 | HIS201 | |
| 6 | GLN250 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| A | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| A | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS328 | activator, hydrogen bond donor |
| A | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| A | PHE390 | activator, hydrogen bond acceptor |
| A | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| B | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| B | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | LYS328 | activator, hydrogen bond donor |
| B | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| B | PHE390 | activator, hydrogen bond acceptor |
| B | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| C | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| C | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | LYS328 | activator, hydrogen bond donor |
| C | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| C | PHE390 | activator, hydrogen bond acceptor |
| C | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| D | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| D | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | LYS328 | activator, hydrogen bond donor |
| D | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| D | PHE390 | activator, hydrogen bond acceptor |
| D | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA5 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| E | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| E | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | LYS328 | activator, hydrogen bond donor |
| E | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| E | PHE390 | activator, hydrogen bond acceptor |
| E | PHE392 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA6 |
| Number of Residues | 6 |
| Details | M-CSA 292 |
| Chain | Residue | Details |
| F | CYS163 | activator, covalently attached, electrostatic stabiliser, hydrogen bond donor, nucleofuge, nucleophile |
| F | HIS298 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | LYS328 | activator, hydrogen bond donor |
| F | HIS333 | electrostatic stabiliser, hydrogen bond donor, increase basicity |
| F | PHE390 | activator, hydrogen bond acceptor |
| F | PHE392 | electrostatic stabiliser, hydrogen bond donor |
