2CCJ
Crystal structure of S. aureus thymidylate kinase complexed with thymidine monophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A1206 |
| Chain | Residue |
| A | ASN132 |
| A | ASN182 |
| B | HOH2080 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A1207 |
| Chain | Residue |
| A | ARG36 |
| A | GLY39 |
| A | LYS77 |
| A | HOH2015 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1208 |
| Chain | Residue |
| A | LEU187 |
| B | HOH2142 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B1206 |
| Chain | Residue |
| A | HOH2149 |
| B | LEU187 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B1207 |
| Chain | Residue |
| A | GLU53 |
| B | ASN132 |
| B | VAL181 |
| B | ASN182 |
| B | HOH2170 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TMP A1209 |
| Chain | Residue |
| A | LYS15 |
| A | GLU37 |
| A | PHE66 |
| A | ARG70 |
| A | ARG92 |
| A | SER97 |
| A | TYR100 |
| A | GLN101 |
| A | HOH2102 |
| A | HOH2105 |
| A | HOH2109 |
| A | HOH2216 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A1210 |
| Chain | Residue |
| A | ARG71 |
| A | LEU74 |
| A | ILE120 |
| A | ASN121 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TMP B1208 |
| Chain | Residue |
| B | GLU11 |
| B | LYS15 |
| B | ARG36 |
| B | ARG70 |
| B | ARG92 |
| B | SER96 |
| B | SER97 |
| B | TYR100 |
| B | GLN101 |
| B | TMP1209 |
| B | HOH2011 |
| B | HOH2115 |
| B | HOH2194 |
| B | HOH2195 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TMP B1209 |
| Chain | Residue |
| B | ALA63 |
| B | PHE66 |
| B | GLN101 |
| B | ARG105 |
| B | TMP1208 |
| B | HOH2066 |
| B | HOH2092 |
| B | HOH2115 |
| B | HOH2195 |
| B | HOH2197 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B1210 |
| Chain | Residue |
| B | ARG71 |
| B | ILE120 |
| B | ASN121 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B1211 |
| Chain | Residue |
| B | GLU37 |
| B | ARG48 |
| B | PHE66 |
| B | SER69 |
| B | ARG70 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. LCDRYidSSlAYQ |
| Chain | Residue | Details |
| A | LEU89-GLN101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
| Chain | Residue | Details |
| A | GLY9 | |
| B | GLY9 |
