2CBX

X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with beta-D-erythrofuranosyl- adenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0033846	molecular_function	adenosyl-fluoride synthase activity
B	0016740	molecular_function	transferase activity
B	0033846	molecular_function	adenosyl-fluoride synthase activity
C	0016740	molecular_function	transferase activity
C	0033846	molecular_function	adenosyl-fluoride synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CC5 A 500

Chain	Residue
A	ASP16
B	ASN215
B	PHE254
B	ARG277
B	ALA279
A	TRP50
A	TYR77
A	PRO78
A	THR80
A	THR155
A	SER158
A	GOL1303
B	PHE213

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CC5 B 500

Chain	Residue
B	ASP16
B	TRP50
B	TYR77
B	PRO78
B	THR80
B	THR155
B	SER158
C	PHE213
C	ASN215
C	PHE254
C	ARG277
C	ALA279

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CC5 C 500

Chain	Residue
A	PHE213
A	ASN215
A	PHE254
A	ARG277
A	ALA279
A	GOL1302
C	ASP16
C	TRP50
C	TYR77
C	PRO78
C	THR80
C	THR155
C	SER158

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A1300

Chain	Residue
A	THR19
A	LYS28
A	ASP42
A	HOH2151
A	HOH2152
A	HOH2153
B	ASP42
B	VAL43
B	HOH2027
B	HOH2168

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A1301

Chain	Residue
A	TYR136
A	HOH2154

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1302

Chain	Residue
A	ASP210
A	TRP217
A	SER269
A	ARG270
A	HOH2119
A	HOH2155
C	ASP21
C	SER23
C	THR155
C	CC5500
C	HOH2096

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A1303

Chain	Residue
A	LEU17
A	SER23
A	THR155
A	PHE156
A	CC5500
A	HOH2089
A	HOH2156
B	PHE213
B	SER269

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A1304

Chain	Residue
A	GLY69
A	ILE118
A	LEU169
A	ALA170
A	HOH2157
C	ALA108

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B1301

Chain	Residue
B	THR19
B	LYS28
B	ASP42
B	HOH2168
B	HOH2169
B	HOH2170
C	ASP42
C	VAL43
C	HOH2024
C	HOH2167

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL C1299

Chain	Residue
A	ASP42
A	VAL43
A	HOH2015
A	HOH2152
C	THR19
C	VAL24
C	LYS28
C	ASP42
C	HOH2166
C	HOH2167
C	HOH2168

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C1300

Chain	Residue
C	TYR136
C	LEU137

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C1301

Chain	Residue
B	ARG277
B	PRO285
B	TYR286
C	ASP241
C	HOH2131

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14765200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16370017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16604208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17985882","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2005","submissionDatabase":"PDB data bank","title":"Substrates and inhibitors of the fluorinase from Streptomyces cattleya.","authors":["Mcewan A.R.","Deng H.","Mcglinchey R.P.","Robinson D.R.","O'Hagan D.","Naismith J.H."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2014","submissionDatabase":"PDB data bank","title":"Structure of a bacterial fluorinating enzyme with.","authors":["Thomson S.","Mcmahon S.A.","Naismith J.H.","O'Hagan D."]}}]}

Chain

Residue

Details

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