2CB3
Crystal structure of peptidoglycan recognition protein-LE in complex with tracheal cytotoxin (monomeric diaminopimelic acid-type peptidoglycan)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008745 | molecular_function | N-acetylmuramoyl-L-alanine amidase activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0042834 | molecular_function | peptidoglycan binding |
| A | 0045087 | biological_process | innate immune response |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008745 | molecular_function | N-acetylmuramoyl-L-alanine amidase activity |
| B | 0009253 | biological_process | peptidoglycan catabolic process |
| B | 0042834 | molecular_function | peptidoglycan binding |
| B | 0045087 | biological_process | innate immune response |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008745 | molecular_function | N-acetylmuramoyl-L-alanine amidase activity |
| C | 0009253 | biological_process | peptidoglycan catabolic process |
| C | 0042834 | molecular_function | peptidoglycan binding |
| C | 0045087 | biological_process | innate immune response |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008745 | molecular_function | N-acetylmuramoyl-L-alanine amidase activity |
| D | 0009253 | biological_process | peptidoglycan catabolic process |
| D | 0042834 | molecular_function | peptidoglycan binding |
| D | 0045087 | biological_process | innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE MLD A1345 |
| Chain | Residue |
| A | HIS206 |
| A | HIS262 |
| A | LEU264 |
| A | ASN267 |
| A | HIS314 |
| A | ASN318 |
| A | THR320 |
| A | GLU321 |
| A | SER322 |
| A | HOH2027 |
| A | HOH2038 |
| A | THR207 |
| A | HOH2040 |
| A | HOH2052 |
| A | HOH2054 |
| B | GLN186 |
| B | ARG223 |
| B | ASP224 |
| B | SER227 |
| B | GLU231 |
| D | ARG215 |
| A | HIS229 |
| A | ARG233 |
| A | TRP235 |
| A | ASN236 |
| A | TYR240 |
| A | ARG254 |
| A | ALA261 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE MLD B1344 |
| Chain | Residue |
| B | HIS206 |
| B | THR207 |
| B | MET225 |
| B | HIS229 |
| B | ARG233 |
| B | TRP235 |
| B | ASN236 |
| B | TYR240 |
| B | ARG254 |
| B | ALA261 |
| B | HIS262 |
| B | ASN267 |
| B | ARG268 |
| B | HIS314 |
| B | ASN318 |
| B | THR320 |
| B | GLU321 |
| B | SER322 |
| B | HOH2026 |
| B | HOH2042 |
| B | HOH2059 |
| B | HOH2060 |
| B | HOH2062 |
| B | HOH2063 |
| C | ARG215 |
| D | ARG223 |
| D | SER227 |
| D | GLU231 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE MLD C1344 |
| Chain | Residue |
| A | ARG223 |
| A | ASP224 |
| A | SER227 |
| A | GLU231 |
| B | ARG215 |
| C | HIS206 |
| C | THR207 |
| C | HIS229 |
| C | ARG233 |
| C | TRP235 |
| C | ASN236 |
| C | TYR240 |
| C | ARG254 |
| C | ALA261 |
| C | HIS262 |
| C | LEU264 |
| C | ASN267 |
| C | HIS314 |
| C | ASN318 |
| C | THR320 |
| C | GLU321 |
| C | SER322 |
| C | HOH2023 |
| C | HOH2033 |
| C | HOH2036 |
| C | HOH2045 |
| C | HOH2048 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE MLD D1344 |
| Chain | Residue |
| D | ASN267 |
| D | HIS314 |
| D | ASN318 |
| D | THR320 |
| D | GLU321 |
| D | SER322 |
| D | HOH2017 |
| D | HOH2031 |
| D | HOH2033 |
| D | HOH2034 |
| D | HOH2035 |
| D | HOH2037 |
| A | ARG215 |
| C | ARG223 |
| C | ASP224 |
| C | SER227 |
| C | GLU231 |
| D | HIS206 |
| D | THR207 |
| D | HIS229 |
| D | ARG233 |
| D | TRP235 |
| D | ASN236 |
| D | TYR240 |
| D | ARG254 |
| D | ALA261 |
| D | HIS262 |
| D | LEU264 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1344 |
| Chain | Residue |
| A | GLU210 |
| A | SER211 |
| A | GLY277 |
| A | CYS278 |
| A | PHE279 |
| A | GLU282 |
| B | HOH2006 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS206 | |
| B | HIS314 | |
| C | HIS206 | |
| C | HIS229 | |
| C | ARG254 | |
| C | ALA261 | |
| C | HIS314 | |
| D | HIS206 | |
| D | HIS229 | |
| D | ARG254 | |
| D | ALA261 | |
| A | HIS229 | |
| D | HIS314 | |
| A | ARG254 | |
| A | ALA261 | |
| A | HIS314 | |
| B | HIS206 | |
| B | HIS229 | |
| B | ARG254 | |
| B | ALA261 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN318 | |
| B | ASN318 | |
| C | ASN318 | |
| D | ASN318 |
