2CAD
NikR from Helicobacter pylori in closed trans-conformation and nickel bound to 2F, 2X and 2I sites.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010045 | biological_process | response to nickel cation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010045 | biological_process | response to nickel cation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NI A1152 |
| Chain | Residue |
| A | HIS74 |
| A | HIS101 |
| A | HOH2022 |
| A | HOH2062 |
| B | HIS88 |
| B | HOH2028 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI B1151 |
| Chain | Residue |
| B | HIS101 |
| B | CYS107 |
| A | ILE84 |
| A | HIS88 |
| B | HIS99 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B1152 |
| Chain | Residue |
| B | HIS74 |
| B | HIS75 |
| B | GLU104 |
| B | CIT1150 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT B1150 |
| Chain | Residue |
| A | HIS88 |
| A | ALA89 |
| A | HOH2029 |
| B | HIS74 |
| B | HIS75 |
| B | GLU104 |
| B | GOL1148 |
| B | NI1152 |
| B | HOH2055 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A1147 |
| Chain | Residue |
| A | ILE84 |
| A | GLN87 |
| A | THR97 |
| A | HIS99 |
| A | GLU109 |
| A | HOH2060 |
| B | HIS99 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT A1148 |
| Chain | Residue |
| A | ALA136 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A1149 |
| Chain | Residue |
| A | GLN76 |
| A | ARG82 |
| A | ARG131 |
| A | FMT1150 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A1150 |
| Chain | Residue |
| A | ARG82 |
| A | LEU130 |
| A | ARG131 |
| A | FMT1149 |
| A | HOH2061 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1151 |
| Chain | Residue |
| A | TYR72 |
| A | ASN80 |
| A | HIS99 |
| A | HOH2062 |
| A | HOH2063 |
| B | GOL1149 |
| B | HOH2028 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B1148 |
| Chain | Residue |
| B | HIS75 |
| B | HIS105 |
| B | CIT1150 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B1149 |
| Chain | Residue |
| A | GOL1151 |
| B | ASN80 |
| B | MET83 |
| B | GLN87 |
| B | THR97 |
| B | GLU109 |
| B | HOH2054 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00476 |
| Chain | Residue | Details |
| A | HIS88 | |
| A | HIS99 | |
| A | HIS101 | |
| A | CYS107 | |
| B | HIS88 | |
| B | HIS99 | |
| B | HIS101 | |
| B | CYS107 |
