2C7N
Human Rabex-5 residues 1-74 in complex with Ubiquitin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016192 | biological_process | vesicle-mediated transport |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016192 | biological_process | vesicle-mediated transport |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0016192 | biological_process | vesicle-mediated transport |
| G | 0003677 | molecular_function | DNA binding |
| G | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0016192 | biological_process | vesicle-mediated transport |
| I | 0003677 | molecular_function | DNA binding |
| I | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0016192 | biological_process | vesicle-mediated transport |
| K | 0003677 | molecular_function | DNA binding |
| K | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| K | 0008270 | molecular_function | zinc ion binding |
| K | 0016192 | biological_process | vesicle-mediated transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 499 |
| Chain | Residue |
| A | CYS19 |
| A | CYS23 |
| A | CYS35 |
| A | CYS38 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 499 |
| Chain | Residue |
| C | CYS19 |
| C | CYS23 |
| C | CYS35 |
| C | CYS38 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 499 |
| Chain | Residue |
| E | CYS23 |
| E | CYS35 |
| E | CYS38 |
| E | CYS19 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN G 499 |
| Chain | Residue |
| G | CYS19 |
| G | CYS23 |
| G | CYS35 |
| G | CYS38 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN I 499 |
| Chain | Residue |
| I | CYS19 |
| I | CYS23 |
| I | CYS35 |
| I | CYS38 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN K 499 |
| Chain | Residue |
| K | CYS19 |
| K | CYS23 |
| K | CYS35 |
| K | CYS38 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| B | ARG54 | |
| J | ARG72 | |
| L | ARG54 | |
| L | ARG72 | |
| B | ARG72 | |
| D | ARG54 | |
| D | ARG72 | |
| F | ARG54 | |
| F | ARG72 | |
| H | ARG54 | |
| H | ARG72 | |
| J | ARG54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| B | HIS68 | |
| E | CYS23 | |
| E | CYS35 | |
| E | CYS38 | |
| G | CYS19 | |
| G | CYS23 | |
| G | CYS35 | |
| G | CYS38 | |
| I | CYS19 | |
| I | CYS23 | |
| I | CYS35 | |
| D | HIS68 | |
| I | CYS38 | |
| K | CYS19 | |
| K | CYS23 | |
| K | CYS35 | |
| K | CYS38 | |
| F | HIS68 | |
| H | HIS68 | |
| J | HIS68 | |
| L | HIS68 | |
| C | CYS35 | |
| C | CYS38 | |
| E | CYS19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| B | SER65 | |
| D | SER65 | |
| F | SER65 | |
| H | SER65 | |
| J | SER65 | |
| L | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| B | GLY76 | |
| D | GLY76 | |
| F | GLY76 | |
| H | GLY76 | |
| J | GLY76 | |
| L | GLY76 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48 |
| Chain | Residue | Details |
| B | LYS6 | |
| D | LYS27 | |
| D | LYS29 | |
| D | LYS33 | |
| D | LYS48 | |
| D | LYS63 | |
| F | LYS6 | |
| F | LYS11 | |
| F | LYS27 | |
| F | LYS29 | |
| F | LYS33 | |
| B | LYS11 | |
| F | LYS48 | |
| F | LYS63 | |
| H | LYS6 | |
| H | LYS11 | |
| H | LYS27 | |
| H | LYS29 | |
| H | LYS33 | |
| H | LYS48 | |
| H | LYS63 | |
| J | LYS6 | |
| B | LYS27 | |
| J | LYS11 | |
| J | LYS27 | |
| J | LYS29 | |
| J | LYS33 | |
| J | LYS48 | |
| J | LYS63 | |
| L | LYS6 | |
| L | LYS11 | |
| L | LYS27 | |
| L | LYS29 | |
| B | LYS29 | |
| L | LYS33 | |
| L | LYS48 | |
| L | LYS63 | |
| B | LYS33 | |
| B | LYS48 | |
| B | LYS63 | |
| D | LYS6 | |
| D | LYS11 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 |
| Chain | Residue | Details |
| J | GLY76 | |
| L | GLY76 | |
| B | GLY76 | |
| D | GLY76 | |
| F | GLY76 | |
| H | GLY76 |
