2C7N

Human Rabex-5 residues 1-74 in complex with Ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0008270	molecular_function	zinc ion binding
G	0003677	molecular_function	DNA binding
G	0008270	molecular_function	zinc ion binding
I	0003677	molecular_function	DNA binding
I	0008270	molecular_function	zinc ion binding
K	0003677	molecular_function	DNA binding
K	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 499

Chain	Residue
A	CYS19
A	CYS23
A	CYS35
A	CYS38

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 499

Chain	Residue
C	CYS19
C	CYS23
C	CYS35
C	CYS38

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 499

Chain	Residue
E	CYS23
E	CYS35
E	CYS38
E	CYS19

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 499

Chain	Residue
G	CYS19
G	CYS23
G	CYS35
G	CYS38

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 499

Chain	Residue
I	CYS19
I	CYS23
I	CYS35
I	CYS38

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 499

Chain	Residue
K	CYS19
K	CYS23
K	CYS35
K	CYS38

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
J	ARG72
L	ARG54
L	ARG72
B	ARG72
D	ARG54
D	ARG72
F	ARG54
F	ARG72
H	ARG54
H	ARG72
J	ARG54

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
E	CYS23
E	CYS35
E	CYS38
G	CYS19
G	CYS23
G	CYS35
G	CYS38
I	CYS19
I	CYS23
I	CYS35
D	HIS68
I	CYS38
K	CYS19
K	CYS23
K	CYS35
K	CYS38
F	HIS68
H	HIS68
J	HIS68
L	HIS68
C	CYS35
C	CYS38
E	CYS19

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	SER65
D	SER65
F	SER65
H	SER65
J	SER65
L	SER65

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	GLY76
D	GLY76
F	GLY76
H	GLY76
J	GLY76
L	GLY76

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
B	LYS6
D	LYS27
D	LYS29
D	LYS33
D	LYS48
D	LYS63
F	LYS6
F	LYS11
F	LYS27
F	LYS29
F	LYS33
B	LYS11
F	LYS48
F	LYS63
H	LYS6
H	LYS11
H	LYS27
H	LYS29
H	LYS33
H	LYS48
H	LYS63
J	LYS6
B	LYS27
J	LYS11
J	LYS27
J	LYS29
J	LYS33
J	LYS48
J	LYS63
L	LYS6
L	LYS11
L	LYS27
L	LYS29
B	LYS29
L	LYS33
L	LYS48
L	LYS63
B	LYS33
B	LYS48
B	LYS63
D	LYS6
D	LYS11

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
J	GLY76
L	GLY76
B	GLY76
D	GLY76
F	GLY76
H	GLY76

---