2C74

14-3-3 Protein Eta (Human) Complexed to Peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002028	biological_process	regulation of sodium ion transport
A	0003779	molecular_function	actin binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006713	biological_process	glucocorticoid catabolic process
A	0006886	biological_process	intracellular protein transport
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0014704	cellular_component	intercalated disc
A	0017080	molecular_function	sodium channel regulator activity
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0021762	biological_process	substantia nigra development
A	0035259	molecular_function	nuclear glucocorticoid receptor binding
A	0042802	molecular_function	identical protein binding
A	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
A	0044325	molecular_function	transmembrane transporter binding
A	0045202	cellular_component	synapse
A	0045664	biological_process	regulation of neuron differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046982	molecular_function	protein heterodimerization activity
A	0048167	biological_process	regulation of synaptic plasticity
A	0050774	biological_process	negative regulation of dendrite morphogenesis
A	0070062	cellular_component	extracellular exosome
A	0086010	biological_process	membrane depolarization during action potential
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse
B	0002028	biological_process	regulation of sodium ion transport
B	0003779	molecular_function	actin binding
B	0005159	molecular_function	insulin-like growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006713	biological_process	glucocorticoid catabolic process
B	0006886	biological_process	intracellular protein transport
B	0007165	biological_process	signal transduction
B	0008104	biological_process	intracellular protein localization
B	0014704	cellular_component	intercalated disc
B	0017080	molecular_function	sodium channel regulator activity
B	0019899	molecular_function	enzyme binding
B	0019904	molecular_function	protein domain specific binding
B	0021762	biological_process	substantia nigra development
B	0035259	molecular_function	nuclear glucocorticoid receptor binding
B	0042802	molecular_function	identical protein binding
B	0042921	biological_process	nuclear receptor-mediated glucocorticoid signaling pathway
B	0044325	molecular_function	transmembrane transporter binding
B	0045202	cellular_component	synapse
B	0045664	biological_process	regulation of neuron differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046982	molecular_function	protein heterodimerization activity
B	0048167	biological_process	regulation of synaptic plasticity
B	0050774	biological_process	negative regulation of dendrite morphogenesis
B	0070062	cellular_component	extracellular exosome
B	0086010	biological_process	membrane depolarization during action potential
B	0098793	cellular_component	presynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
B	0150048	cellular_component	cerebellar granule cell to Purkinje cell synapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CIT A 1237

Chain	Residue
A	LYS88
A	PHE115
A	GLN116
A	SER119
B	ARG10

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Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR216-SER235

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68510","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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