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2C63

14-3-3 Protein Eta (Human) Complexed to Peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0002028biological_processregulation of sodium ion transport
A0003779molecular_functionactin binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006713biological_processglucocorticoid catabolic process
A0006886biological_processintracellular protein transport
A0007165biological_processsignal transduction
A0014704cellular_componentintercalated disc
A0017080molecular_functionsodium channel regulator activity
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0021762biological_processsubstantia nigra development
A0035259molecular_functionnuclear glucocorticoid receptor binding
A0042802molecular_functionidentical protein binding
A0042921biological_processintracellular glucocorticoid receptor signaling pathway
A0044325molecular_functiontransmembrane transporter binding
A0045664biological_processregulation of neuron differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046982molecular_functionprotein heterodimerization activity
A0048167biological_processregulation of synaptic plasticity
A0050774biological_processnegative regulation of dendrite morphogenesis
A0070062cellular_componentextracellular exosome
A0086010biological_processmembrane depolarization during action potential
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0150048cellular_componentcerebellar granule cell to Purkinje cell synapse
A2000649biological_processregulation of sodium ion transmembrane transporter activity
B0002028biological_processregulation of sodium ion transport
B0003779molecular_functionactin binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006713biological_processglucocorticoid catabolic process
B0006886biological_processintracellular protein transport
B0007165biological_processsignal transduction
B0014704cellular_componentintercalated disc
B0017080molecular_functionsodium channel regulator activity
B0019899molecular_functionenzyme binding
B0019904molecular_functionprotein domain specific binding
B0021762biological_processsubstantia nigra development
B0035259molecular_functionnuclear glucocorticoid receptor binding
B0042802molecular_functionidentical protein binding
B0042921biological_processintracellular glucocorticoid receptor signaling pathway
B0044325molecular_functiontransmembrane transporter binding
B0045664biological_processregulation of neuron differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046982molecular_functionprotein heterodimerization activity
B0048167biological_processregulation of synaptic plasticity
B0050774biological_processnegative regulation of dendrite morphogenesis
B0070062cellular_componentextracellular exosome
B0086010biological_processmembrane depolarization during action potential
B0098793cellular_componentpresynapse
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0150048cellular_componentcerebellar granule cell to Purkinje cell synapse
B2000649biological_processregulation of sodium ion transmembrane transporter activity
C0002028biological_processregulation of sodium ion transport
C0003779molecular_functionactin binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006713biological_processglucocorticoid catabolic process
C0006886biological_processintracellular protein transport
C0007165biological_processsignal transduction
C0014704cellular_componentintercalated disc
C0017080molecular_functionsodium channel regulator activity
C0019899molecular_functionenzyme binding
C0019904molecular_functionprotein domain specific binding
C0021762biological_processsubstantia nigra development
C0035259molecular_functionnuclear glucocorticoid receptor binding
C0042802molecular_functionidentical protein binding
C0042921biological_processintracellular glucocorticoid receptor signaling pathway
C0044325molecular_functiontransmembrane transporter binding
C0045664biological_processregulation of neuron differentiation
C0045893biological_processpositive regulation of DNA-templated transcription
C0046982molecular_functionprotein heterodimerization activity
C0048167biological_processregulation of synaptic plasticity
C0050774biological_processnegative regulation of dendrite morphogenesis
C0070062cellular_componentextracellular exosome
C0086010biological_processmembrane depolarization during action potential
C0098793cellular_componentpresynapse
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C0150048cellular_componentcerebellar granule cell to Purkinje cell synapse
C2000649biological_processregulation of sodium ion transmembrane transporter activity
D0002028biological_processregulation of sodium ion transport
D0003779molecular_functionactin binding
D0005159molecular_functioninsulin-like growth factor receptor binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006713biological_processglucocorticoid catabolic process
D0006886biological_processintracellular protein transport
D0007165biological_processsignal transduction
D0014704cellular_componentintercalated disc
D0017080molecular_functionsodium channel regulator activity
D0019899molecular_functionenzyme binding
D0019904molecular_functionprotein domain specific binding
D0021762biological_processsubstantia nigra development
D0035259molecular_functionnuclear glucocorticoid receptor binding
D0042802molecular_functionidentical protein binding
D0042921biological_processintracellular glucocorticoid receptor signaling pathway
D0044325molecular_functiontransmembrane transporter binding
D0045664biological_processregulation of neuron differentiation
D0045893biological_processpositive regulation of DNA-templated transcription
D0046982molecular_functionprotein heterodimerization activity
D0048167biological_processregulation of synaptic plasticity
D0050774biological_processnegative regulation of dendrite morphogenesis
D0070062cellular_componentextracellular exosome
D0086010biological_processmembrane depolarization during action potential
D0098793cellular_componentpresynapse
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0150048cellular_componentcerebellar granule cell to Purkinje cell synapse
D2000649biological_processregulation of sodium ion transmembrane transporter activity
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR216-SER235

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
ASER58
ATYR133
BSER58
BTYR133
CSER58
CTYR133
DSER58
DTYR133

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N-acetylglycine => ECO:0000269|Ref.11
ChainResidueDetails
AASP3
BASP3
CASP3
DASP3

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
AALA26
BALA26
CALA26
DALA26

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68510
ChainResidueDetails
ATRP60
BTRP60
CTRP60
DTRP60

218853

PDB entries from 2024-04-24

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