2C57
H.pylori type II dehydroquinase in complex with FA1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019631 | biological_process | quinate catabolic process |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019631 | biological_process | quinate catabolic process |
| C | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019631 | biological_process | quinate catabolic process |
| D | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019631 | biological_process | quinate catabolic process |
| E | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019631 | biological_process | quinate catabolic process |
| F | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019631 | biological_process | quinate catabolic process |
| G | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019631 | biological_process | quinate catabolic process |
| H | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0019631 | biological_process | quinate catabolic process |
| I | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| I | 0009423 | biological_process | chorismate biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0019631 | biological_process | quinate catabolic process |
| J | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| J | 0009423 | biological_process | chorismate biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0019631 | biological_process | quinate catabolic process |
| K | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| K | 0009423 | biological_process | chorismate biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| K | 0019631 | biological_process | quinate catabolic process |
| L | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| L | 0009423 | biological_process | chorismate biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
| L | 0019631 | biological_process | quinate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 A1159 |
| Chain | Residue |
| A | ASN76 |
| A | GLY78 |
| A | ALA79 |
| A | HIS82 |
| A | HIS102 |
| A | LEU103 |
| A | THR104 |
| A | ARG113 |
| B | ASP89 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 B1159 |
| Chain | Residue |
| B | ASN76 |
| B | GLY78 |
| B | ALA79 |
| B | HIS82 |
| B | HIS102 |
| B | LEU103 |
| B | THR104 |
| B | ARG113 |
| C | ASP89 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 C1159 |
| Chain | Residue |
| A | ASP89 |
| C | ASN76 |
| C | GLY78 |
| C | ALA79 |
| C | HIS82 |
| C | HIS102 |
| C | LEU103 |
| C | THR104 |
| C | ARG113 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 D1159 |
| Chain | Residue |
| D | ASN76 |
| D | GLY78 |
| D | ALA79 |
| D | HIS82 |
| D | HIS102 |
| D | LEU103 |
| D | THR104 |
| D | ARG113 |
| E | ASP89 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 E1159 |
| Chain | Residue |
| E | ASN76 |
| E | GLY78 |
| E | ALA79 |
| E | HIS82 |
| E | HIS102 |
| E | LEU103 |
| E | THR104 |
| E | ARG113 |
| F | ASP89 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 F1159 |
| Chain | Residue |
| D | ASP89 |
| F | ASN76 |
| F | GLY78 |
| F | ALA79 |
| F | HIS82 |
| F | HIS102 |
| F | LEU103 |
| F | THR104 |
| F | ARG113 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 G1159 |
| Chain | Residue |
| G | ASN76 |
| G | GLY78 |
| G | ALA79 |
| G | HIS82 |
| G | HIS102 |
| G | LEU103 |
| G | THR104 |
| G | ARG113 |
| H | ASP89 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 H1159 |
| Chain | Residue |
| H | ASN76 |
| H | GLY78 |
| H | ALA79 |
| H | HIS82 |
| H | HIS102 |
| H | LEU103 |
| H | THR104 |
| H | ARG113 |
| I | ASP89 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 I1159 |
| Chain | Residue |
| G | ASP89 |
| I | ASN76 |
| I | GLY78 |
| I | ALA79 |
| I | HIS82 |
| I | HIS102 |
| I | LEU103 |
| I | THR104 |
| I | ARG113 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 J1159 |
| Chain | Residue |
| J | ASN76 |
| J | GLY78 |
| J | ALA79 |
| J | HIS82 |
| J | HIS102 |
| J | LEU103 |
| J | THR104 |
| J | ARG113 |
| K | ASP89 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 K1159 |
| Chain | Residue |
| K | ASN76 |
| K | GLY78 |
| K | ALA79 |
| K | HIS82 |
| K | HIS102 |
| K | LEU103 |
| K | THR104 |
| K | ARG113 |
| L | ASP89 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FA1 L1159 |
| Chain | Residue |
| J | ASP89 |
| L | ASN76 |
| L | GLY78 |
| L | ALA79 |
| L | HIS82 |
| L | HIS102 |
| L | LEU103 |
| L | THR104 |
| L | ARG113 |
Functional Information from PROSITE/UniProt
| site_id | PS01029 |
| Number of Residues | 18 |
| Details | DEHYDROQUINASE_II Dehydroquinase class II signature. IQGPNLnmLGhRDprlYG |
| Chain | Residue | Details |
| A | ILE6-GLY23 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | TYR22 | |
| J | TYR22 | |
| K | TYR22 | |
| L | TYR22 | |
| B | TYR22 | |
| C | TYR22 | |
| D | TYR22 | |
| E | TYR22 | |
| F | TYR22 | |
| G | TYR22 | |
| H | TYR22 | |
| I | TYR22 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS102 | |
| J | HIS102 | |
| K | HIS102 | |
| L | HIS102 | |
| B | HIS102 | |
| C | HIS102 | |
| D | HIS102 | |
| E | HIS102 | |
| F | HIS102 | |
| G | HIS102 | |
| H | HIS102 | |
| I | HIS102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12784220 |
| Chain | Residue | Details |
| A | ASN76 | |
| C | HIS82 | |
| C | ASP89 | |
| C | ARG113 | |
| D | ASN76 | |
| D | HIS82 | |
| D | ASP89 | |
| D | ARG113 | |
| E | ASN76 | |
| E | HIS82 | |
| E | ASP89 | |
| A | HIS82 | |
| E | ARG113 | |
| F | ASN76 | |
| F | HIS82 | |
| F | ASP89 | |
| F | ARG113 | |
| G | ASN76 | |
| G | HIS82 | |
| G | ASP89 | |
| G | ARG113 | |
| H | ASN76 | |
| A | ASP89 | |
| H | HIS82 | |
| H | ASP89 | |
| H | ARG113 | |
| I | ASN76 | |
| I | HIS82 | |
| I | ASP89 | |
| I | ARG113 | |
| J | ASN76 | |
| J | HIS82 | |
| J | ASP89 | |
| A | ARG113 | |
| J | ARG113 | |
| K | ASN76 | |
| K | HIS82 | |
| K | ASP89 | |
| K | ARG113 | |
| L | ASN76 | |
| L | HIS82 | |
| L | ASP89 | |
| L | ARG113 | |
| B | ASN76 | |
| B | HIS82 | |
| B | ASP89 | |
| B | ARG113 | |
| C | ASN76 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU103 | |
| J | LEU103 | |
| K | LEU103 | |
| L | LEU103 | |
| B | LEU103 | |
| C | LEU103 | |
| D | LEU103 | |
| E | LEU103 | |
| F | LEU103 | |
| G | LEU103 | |
| H | LEU103 | |
| I | LEU103 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | ARG17 | |
| J | ARG17 | |
| K | ARG17 | |
| L | ARG17 | |
| B | ARG17 | |
| C | ARG17 | |
| D | ARG17 | |
| E | ARG17 | |
| F | ARG17 | |
| G | ARG17 | |
| H | ARG17 | |
| I | ARG17 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| A | HIS102 | |
| A | ARG109 | |
| A | ASN10 | |
| A | GLU100 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| J | HIS102 | |
| J | ARG109 | |
| J | ASN10 | |
| J | GLU100 |
| site_id | CSA11 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| K | HIS102 | |
| K | ARG109 | |
| K | GLU100 | |
| K | ASN10 | |
| K | ARG17 |
| site_id | CSA12 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| L | HIS102 | |
| L | ARG109 | |
| L | GLU100 | |
| L | ASN10 | |
| L | ARG17 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| B | HIS102 | |
| B | ARG109 | |
| B | GLU100 | |
| B | ASN10 | |
| B | ARG17 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| C | HIS102 | |
| C | ARG109 | |
| C | GLU100 | |
| C | ASN10 | |
| C | ARG17 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| D | HIS102 | |
| D | ARG109 | |
| D | ASN10 | |
| D | GLU100 |
| site_id | CSA5 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| E | HIS102 | |
| E | ARG109 | |
| E | GLU100 | |
| E | ASN10 | |
| E | ARG17 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| F | HIS102 | |
| F | ARG109 | |
| F | GLU100 | |
| F | ASN10 | |
| F | ARG17 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| G | HIS102 | |
| G | ARG109 | |
| G | ASN10 | |
| G | GLU100 |
| site_id | CSA8 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| H | HIS102 | |
| H | ARG109 | |
| H | GLU100 | |
| H | ASN10 | |
| H | ARG17 |
| site_id | CSA9 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1uqr |
| Chain | Residue | Details |
| I | HIS102 | |
| I | ARG109 | |
| I | GLU100 | |
| I | ASN10 | |
| I | ARG17 |
