Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2C57

H.pylori type II dehydroquinase in complex with FA1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003855	molecular_function	3-dehydroquinate dehydratase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019631	biological_process	quinate catabolic process
B	0003855	molecular_function	3-dehydroquinate dehydratase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019631	biological_process	quinate catabolic process
C	0003855	molecular_function	3-dehydroquinate dehydratase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019631	biological_process	quinate catabolic process
D	0003855	molecular_function	3-dehydroquinate dehydratase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0016829	molecular_function	lyase activity
D	0019631	biological_process	quinate catabolic process
E	0003855	molecular_function	3-dehydroquinate dehydratase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0009423	biological_process	chorismate biosynthetic process
E	0016829	molecular_function	lyase activity
E	0019631	biological_process	quinate catabolic process
F	0003855	molecular_function	3-dehydroquinate dehydratase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0009423	biological_process	chorismate biosynthetic process
F	0016829	molecular_function	lyase activity
F	0019631	biological_process	quinate catabolic process
G	0003855	molecular_function	3-dehydroquinate dehydratase activity
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0009423	biological_process	chorismate biosynthetic process
G	0016829	molecular_function	lyase activity
G	0019631	biological_process	quinate catabolic process
H	0003855	molecular_function	3-dehydroquinate dehydratase activity
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0009423	biological_process	chorismate biosynthetic process
H	0016829	molecular_function	lyase activity
H	0019631	biological_process	quinate catabolic process
I	0003855	molecular_function	3-dehydroquinate dehydratase activity
I	0008652	biological_process	amino acid biosynthetic process
I	0009073	biological_process	aromatic amino acid family biosynthetic process
I	0009423	biological_process	chorismate biosynthetic process
I	0016829	molecular_function	lyase activity
I	0019631	biological_process	quinate catabolic process
J	0003855	molecular_function	3-dehydroquinate dehydratase activity
J	0008652	biological_process	amino acid biosynthetic process
J	0009073	biological_process	aromatic amino acid family biosynthetic process
J	0009423	biological_process	chorismate biosynthetic process
J	0016829	molecular_function	lyase activity
J	0019631	biological_process	quinate catabolic process
K	0003855	molecular_function	3-dehydroquinate dehydratase activity
K	0008652	biological_process	amino acid biosynthetic process
K	0009073	biological_process	aromatic amino acid family biosynthetic process
K	0009423	biological_process	chorismate biosynthetic process
K	0016829	molecular_function	lyase activity
K	0019631	biological_process	quinate catabolic process
L	0003855	molecular_function	3-dehydroquinate dehydratase activity
L	0008652	biological_process	amino acid biosynthetic process
L	0009073	biological_process	aromatic amino acid family biosynthetic process
L	0009423	biological_process	chorismate biosynthetic process
L	0016829	molecular_function	lyase activity
L	0019631	biological_process	quinate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 A1159

Chain	Residue
A	ASN76
A	GLY78
A	ALA79
A	HIS82
A	HIS102
A	LEU103
A	THR104
A	ARG113
B	ASP89

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 B1159

Chain	Residue
B	ASN76
B	GLY78
B	ALA79
B	HIS82
B	HIS102
B	LEU103
B	THR104
B	ARG113
C	ASP89

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 C1159

Chain	Residue
A	ASP89
C	ASN76
C	GLY78
C	ALA79
C	HIS82
C	HIS102
C	LEU103
C	THR104
C	ARG113

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 D1159

Chain	Residue
D	ASN76
D	GLY78
D	ALA79
D	HIS82
D	HIS102
D	LEU103
D	THR104
D	ARG113
E	ASP89

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 E1159

Chain	Residue
E	ASN76
E	GLY78
E	ALA79
E	HIS82
E	HIS102
E	LEU103
E	THR104
E	ARG113
F	ASP89

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 F1159

Chain	Residue
D	ASP89
F	ASN76
F	GLY78
F	ALA79
F	HIS82
F	HIS102
F	LEU103
F	THR104
F	ARG113

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 G1159

Chain	Residue
G	ASN76
G	GLY78
G	ALA79
G	HIS82
G	HIS102
G	LEU103
G	THR104
G	ARG113
H	ASP89

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 H1159

Chain	Residue
H	ASN76
H	GLY78
H	ALA79
H	HIS82
H	HIS102
H	LEU103
H	THR104
H	ARG113
I	ASP89

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 I1159

Chain	Residue
G	ASP89
I	ASN76
I	GLY78
I	ALA79
I	HIS82
I	HIS102
I	LEU103
I	THR104
I	ARG113

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 J1159

Chain	Residue
J	ASN76
J	GLY78
J	ALA79
J	HIS82
J	HIS102
J	LEU103
J	THR104
J	ARG113
K	ASP89

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 K1159

Chain	Residue
K	ASN76
K	GLY78
K	ALA79
K	HIS82
K	HIS102
K	LEU103
K	THR104
K	ARG113
L	ASP89

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FA1 L1159

Chain	Residue
J	ASP89
L	ASN76
L	GLY78
L	ALA79
L	HIS82
L	HIS102
L	LEU103
L	THR104
L	ARG113

Functional Information from PROSITE/UniProt

site_id	PS01029
Number of Residues	18
Details	DEHYDROQUINASE_II Dehydroquinase class II signature. IQGPNLnmLGhRDprlYG

Chain	Residue	Details
A	ILE6-GLY23

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	TYR22
B	TYR22
C	TYR22
D	TYR22
E	TYR22
F	TYR22
G	TYR22
H	TYR22
I	TYR22
J	TYR22
K	TYR22
L	TYR22

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	HIS102
B	HIS102
C	HIS102
D	HIS102
E	HIS102
F	HIS102
G	HIS102
H	HIS102
I	HIS102
J	HIS102
K	HIS102
L	HIS102

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:12784220

Chain	Residue	Details
A	ASN76
A	HIS82
A	ASP89
A	ARG113
B	ASN76
B	HIS82
B	ASP89
B	ARG113
C	ASN76
C	HIS82
C	ASP89
C	ARG113
D	ASN76
D	HIS82
D	ASP89
D	ARG113
E	ASN76
E	HIS82
E	ASP89
E	ARG113
F	ASN76
F	HIS82
F	ASP89
F	ARG113
G	ASN76
G	HIS82
G	ASP89
G	ARG113
H	ASN76
H	HIS82
H	ASP89
H	ARG113
I	ASN76
I	HIS82
I	ASP89
I	ARG113
J	ASN76
J	HIS82
J	ASP89
J	ARG113
K	ASN76
K	HIS82
K	ASP89
K	ARG113
L	ASN76
L	HIS82
L	ASP89
L	ARG113

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LEU103
B	LEU103
C	LEU103
D	LEU103
E	LEU103
F	LEU103
G	LEU103
H	LEU103
I	LEU103
J	LEU103
K	LEU103
L	LEU103

site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ARG17
B	ARG17
C	ARG17
D	ARG17
E	ARG17
F	ARG17
G	ARG17
H	ARG17
I	ARG17
J	ARG17
K	ARG17
L	ARG17

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)