2C3Z

Crystal structure of a truncated variant of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	tryptophan biosynthetic process
A	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
A	0004640	molecular_function	phosphoribosylanthranilate isomerase activity
A	0006568	biological_process	tryptophan metabolic process
A	0016830	molecular_function	carbon-carbon lyase activity
A	0016831	molecular_function	carboxy-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A1000

Chain	Residue
A	LYS53
A	ARG182
A	GLY212
A	ILE232
A	GLY233
A	SER234
A	HOH2121
A	HOH2130

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Functional Information from PROSITE/UniProt

site_id	PS00614
Number of Residues	15
Details	IGPS Indole-3-glycerol phosphate synthase signature. IIaEYKRKSPSgld....V

Chain	Residue	Details
A	ILE48-VAL62

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1pii

Chain	Residue	Details
A	GLU51
A	SER211
A	ASN180
A	LYS53
A	LYS110
A	GLU159

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site_id	MCSA1
Number of Residues	7
Details	M-CSA 252

Chain	Residue	Details
A	GLU51	electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity, proton acceptor, proton donor
A	LYS53	electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor
A	LYS110	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU159	activator, hydrogen bond acceptor, increase nucleophilicity
A	ASN180	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase acidity
A	GLU210	electrostatic stabiliser
A	SER211	electrostatic stabiliser, hydrogen bond donor

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