2C3E

The bovine mitochondrial ADP-ATP carrier

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005471	molecular_function	ATP:ADP antiporter activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005757	cellular_component	mitochondrial permeability transition pore complex
A	0015297	molecular_function	antiporter activity
A	0015866	biological_process	ADP transport
A	0016020	cellular_component	membrane
A	0017077	molecular_function	oxidative phosphorylation uncoupler activity
A	0031966	cellular_component	mitochondrial membrane
A	0046902	biological_process	regulation of mitochondrial membrane permeability
A	0055085	biological_process	transmembrane transport
A	0140021	biological_process	mitochondrial ADP transmembrane transport
A	1901029	biological_process	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A	1901526	biological_process	positive regulation of mitophagy
A	1902600	biological_process	proton transmembrane transport
A	1990544	biological_process	mitochondrial ATP transmembrane transport
A	1990845	biological_process	adaptive thermogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CXT A 401

Chain	Residue
A	ARG79
A	SER227
A	PHE230
A	ASP231
A	ARG234
A	ASN87
A	LYS91
A	GLY123
A	SER126
A	LEU127
A	GLY182
A	TYR186
A	ARG187

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDL A 800

Chain	Residue
A	ALA19
A	THR23
A	TRP70
A	ARG71
A	GLY72
A	ASN73
A	LEU74
A	PHE81
A	GLY155
A	LEU156
A	GLY157
A	ASN158

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDL A 801

Chain	Residue
A	LEU35
A	GLY52
A	ILE53
A	ILE54
A	LEU225
A	LYS267
A	PHE270
A	LYS271
A	GLY272
A	ALA273
A	TRP274
A	SER275

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CDL A 802

Chain	Residue
A	TYR94
A	THR125
A	CYS128
A	TYR173
A	GLN174
A	GLY175
A	PHE176
A	ASN177
A	GLN181
A	GLY252
A	THR253
A	VAL254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	124
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16226253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	92
Details	Repeat: {"description":"Solcar 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	90
Details	Repeat: {"description":"Solcar 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	Region: {"description":"Important for transport activity","evidences":[{"source":"UniProtKB","id":"P12235","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	Motif: {"description":"Nucleotide carrier signature motif","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14603310","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"7076130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q05962","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P48962","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q05962","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---