2C3E
The bovine mitochondrial ADP-ATP carrier
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005471 | molecular_function | ATP:ADP antiporter activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005757 | cellular_component | mitochondrial permeability transition pore complex |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015866 | biological_process | ADP transport |
| A | 0016020 | cellular_component | membrane |
| A | 0017077 | molecular_function | oxidative phosphorylation uncoupler activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0046902 | biological_process | regulation of mitochondrial membrane permeability |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| A | 1901029 | biological_process | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| A | 1901526 | biological_process | positive regulation of mitophagy |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
| A | 1990845 | biological_process | adaptive thermogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CXT A 401 |
| Chain | Residue |
| A | ARG79 |
| A | SER227 |
| A | PHE230 |
| A | ASP231 |
| A | ARG234 |
| A | ASN87 |
| A | LYS91 |
| A | GLY123 |
| A | SER126 |
| A | LEU127 |
| A | GLY182 |
| A | TYR186 |
| A | ARG187 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL A 800 |
| Chain | Residue |
| A | ALA19 |
| A | THR23 |
| A | TRP70 |
| A | ARG71 |
| A | GLY72 |
| A | ASN73 |
| A | LEU74 |
| A | PHE81 |
| A | GLY155 |
| A | LEU156 |
| A | GLY157 |
| A | ASN158 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL A 801 |
| Chain | Residue |
| A | LEU35 |
| A | GLY52 |
| A | ILE53 |
| A | ILE54 |
| A | LEU225 |
| A | LYS267 |
| A | PHE270 |
| A | LYS271 |
| A | GLY272 |
| A | ALA273 |
| A | TRP274 |
| A | SER275 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL A 802 |
| Chain | Residue |
| A | TYR94 |
| A | THR125 |
| A | CYS128 |
| A | TYR173 |
| A | GLN174 |
| A | GLY175 |
| A | PHE176 |
| A | ASN177 |
| A | GLN181 |
| A | GLY252 |
| A | THR253 |
| A | VAL254 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000305 |
| Chain | Residue | Details |
| A | SER1-PHE7 | |
| A | GLY100-TRP109 | |
| A | MET200-ILE210 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | LEU8-VAL37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000305 |
| Chain | Residue | Details |
| A | GLN38-LEU74 | |
| A | TYR131-VAL178 | |
| A | THR232-ALA273 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | ALA75-LEU99 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | ARG110-VAL130 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | SER179-GLY199 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | VAL211-ASP231 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:14603310, ECO:0000269|PubMed:16226253 |
| Chain | Residue | Details |
| A | TRP274-ASP291 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14603310 |
| Chain | Residue | Details |
| A | TYR80 | |
| A | ASP92 | |
| A | ARG235 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:7076130 |
| Chain | Residue | Details |
| A | ASP2 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q05962 |
| Chain | Residue | Details |
| A | PHE7 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY52 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48962 |
| Chain | Residue | Details |
| A | GLY147 | |
| A | GLY245 | |
| A | GLY272 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q05962 |
| Chain | Residue | Details |
| A | ILE160 |
