2C32
Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D-crystals
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002088 | biological_process | lens development in camera-type eye |
| A | 0005212 | molecular_function | structural constituent of eye lens |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006833 | biological_process | water transport |
| A | 0007601 | biological_process | visual perception |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0034109 | biological_process | homotypic cell-cell adhesion |
| A | 0036438 | biological_process | maintenance of lens transparency |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0098631 | molecular_function | cell adhesion mediator activity |
| A | 1990349 | biological_process | gap junction-mediated intercellular transport |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15377788 |
| Chain | Residue | Details |
| A | MET1-PHE9 | |
| A | GLY60-HIS61 | |
| A | GLY78-SER82 | |
| A | TYR149-ARG156 | |
| A | LEU223-LEU263 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | TRP10-GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:15377788 |
| Chain | Residue | Details |
| A | ALA30-VAL41 | |
| A | VAL107-VAL127 | |
| A | MET176-TYR178 | |
| A | LEU194-ASN200 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | LEU42-VAL59 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | ILE62-VAL77 | |
| A | THR179-ILE193 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | LEU83-SER106 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | GLY128-THR148 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | LEU157-GLY175 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:15377788, ECO:0007744|PDB:1YMG |
| Chain | Residue | Details |
| A | HIS201-LEU222 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Important for water channel gating => ECO:0000269|PubMed:23893133 |
| Chain | Residue | Details |
| A | TYR149 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Interaction with BFSP1 => ECO:0000269|PubMed:28259670 |
| Chain | Residue | Details |
| A | ASN246 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | SITE: interaction with BFSP1 => ECO:0000269|PubMed:28259670 |
| Chain | Residue | Details |
| A | GLU250 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:9375569 |
| Chain | Residue | Details |
| A | SER235 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:2176601 |
| Chain | Residue | Details |
| A | SER243 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:2176601 |
| Chain | Residue | Details |
| A | SER245 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Deamidated asparagine => ECO:0000269|PubMed:2176601 |
| Chain | Residue | Details |
| A | ASN246 |
