2C23
14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004860 | molecular_function | protein kinase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005773 | cellular_component | vacuole |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006605 | biological_process | protein targeting |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | protein localization |
| A | 0016020 | cellular_component | membrane |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0035308 | biological_process | negative regulation of protein dephosphorylation |
| A | 0042470 | cellular_component | melanosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042826 | molecular_function | histone deacetylase binding |
| A | 0043085 | biological_process | positive regulation of catalytic activity |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0051220 | biological_process | cytoplasmic sequestering of protein |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with phosphoserine on interacting protein => ECO:0000250 |
| Chain | Residue | Details |
| A | SER59 | |
| A | TYR130 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine; in 14-3-3 protein beta/alpha; alternate => ECO:0000269|Ref.7, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | THR2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | MET3 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27348 |
| Chain | Residue | Details |
| A | SER6 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P27348 |
| Chain | Residue | Details |
| A | ASN52 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CQV8 |
| Chain | Residue | Details |
| A | TRP61 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | THR71 | |
| A | VAL118 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q9CQV8 |
| Chain | Residue | Details |
| A | ARG85 | |
| A | LEU107 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68251 |
| Chain | Residue | Details |
| A | PRO187 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | GLU233 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P27348 |
| Chain | Residue | Details |
| A | ASN52 |
