2C0C
Structure of the MGC45594 gene product
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0045599 | biological_process | negative regulation of fat cell differentiation |
| A | 0047522 | molecular_function | 15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005777 | cellular_component | peroxisome |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0045599 | biological_process | negative regulation of fat cell differentiation |
| B | 0047522 | molecular_function | 15-oxoprostaglandin 13-reductase [NAD(P)+] activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP A1363 |
| Chain | Residue |
| A | ASN66 |
| A | LYS200 |
| A | TYR215 |
| A | SER238 |
| A | ILE260 |
| A | GLY261 |
| A | PHE262 |
| A | ILE263 |
| A | SER264 |
| A | TYR266 |
| A | PHE294 |
| A | ALA67 |
| A | LEU296 |
| A | MET347 |
| A | ASN352 |
| A | HOH2073 |
| A | HOH2075 |
| A | HOH2174 |
| A | HOH2188 |
| A | HOH2195 |
| A | HOH2254 |
| A | HOH2258 |
| A | THR150 |
| A | HOH2348 |
| A | HOH2349 |
| A | HOH2350 |
| A | HOH2351 |
| A | HOH2352 |
| A | HOH2353 |
| A | HOH2354 |
| A | ALA171 |
| A | GLY174 |
| A | GLY175 |
| A | THR176 |
| A | CYS195 |
| A | SER196 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE NAP B1363 |
| Chain | Residue |
| B | ASN66 |
| B | ALA67 |
| B | THR150 |
| B | ALA171 |
| B | GLY174 |
| B | GLY175 |
| B | THR176 |
| B | CYS195 |
| B | SER196 |
| B | LYS200 |
| B | TYR215 |
| B | SER238 |
| B | VAL239 |
| B | ILE260 |
| B | GLY261 |
| B | PHE262 |
| B | ILE263 |
| B | SER264 |
| B | TYR266 |
| B | PHE294 |
| B | LEU296 |
| B | MET347 |
| B | TYR348 |
| B | ASN352 |
| B | HOH2074 |
| B | HOH2075 |
| B | HOH2155 |
| B | HOH2226 |
| B | HOH2309 |
| B | HOH2312 |
| B | HOH2313 |
| B | HOH2314 |
| B | HOH2315 |
| B | HOH2316 |
| B | HOH2317 |
| B | HOH2318 |
| B | HOH2319 |
| B | HOH2320 |
Functional Information from PROSITE/UniProt
| site_id | PS01162 |
| Number of Residues | 22 |
| Details | QOR_ZETA_CRYSTAL Quinone oxidoreductase / zeta-crystallin signature. GKkvLvtaAAGGtGqfamQlsK |
| Chain | Residue | Details |
| A | GLY164-LYS185 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"The structure of MGC45594 gene product.","authors":["Bunkoczi G.","Shafqat N.","Guo K.","Smee C.","Arrowsmith C.","Edwards A.","Weigelt J.","Sundstrom M.","Gileadi O.","Von Delft F.","Oppermann U."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BGC4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | TYR77 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | TYR77 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | SER68 | |
| A | ASN71 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | SER68 | |
| B | ASN71 |
