2BYT
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0002161 | molecular_function | aminoacyl-tRNA deacylase activity |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004823 | molecular_function | leucine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| D | 0016874 | molecular_function | ligase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1302 |
| Chain | Residue |
| A | CYS439 |
| A | CYS442 |
| A | CYS484 |
| A | CYS487 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1303 |
| Chain | Residue |
| A | CYS159 |
| A | CYS162 |
| A | CYS176 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A1304 |
| Chain | Residue |
| A | CYS128 |
| A | GLU129 |
| A | TYR102 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A1501 |
| Chain | Residue |
| A | GLY716 |
| A | LYS717 |
| A | ARG762 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1502 |
| Chain | Residue |
| A | GLY707 |
| A | ARG769 |
| A | ARG773 |
| A | TRP795 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1503 |
| Chain | Residue |
| A | HIS49 |
| A | HIS52 |
| A | SER639 |
| A | LYS640 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A1504 |
| Chain | Residue |
| A | ARG759 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A1505 |
| Chain | Residue |
| A | ARG187 |
| A | GLU188 |
| A | LYS288 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1506 |
| Chain | Residue |
| A | ARG32 |
| A | TYR71 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1509 |
| Chain | Residue |
| A | VAL564 |
| A | GLU565 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1510 |
| Chain | Residue |
| A | LEU329 |
| A | PHE330 |
| A | GLY331 |
| A | ARG420 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A1511 |
| Chain | Residue |
| A | VAL637 |
| A | LYS642 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D1602 |
| Chain | Residue |
| D | CYS439 |
| D | CYS442 |
| D | CYS484 |
| D | CYS487 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D1603 |
| Chain | Residue |
| D | CYS159 |
| D | CYS162 |
| D | CYS176 |
| D | HIS179 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG D1604 |
| Chain | Residue |
| D | TYR102 |
| D | CYS128 |
| D | GLU129 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D1701 |
| Chain | Residue |
| D | LYS26 |
| D | ASP27 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1702 |
| Chain | Residue |
| D | GLY707 |
| D | ARG769 |
| D | ARG773 |
| D | TRP795 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1703 |
| Chain | Residue |
| D | HIS49 |
| D | HIS52 |
| D | SER639 |
| D | LYS640 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 D1704 |
| Chain | Residue |
| D | ARG759 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D1708 |
| Chain | Residue |
| D | GLU208 |
| D | LYS217 |
| D | ARG221 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1710 |
| Chain | Residue |
| D | LEU329 |
| D | PHE330 |
| D | GLY331 |
| D | ARG420 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LEU A1301 |
| Chain | Residue |
| A | MET40 |
| A | PHE41 |
| A | PRO42 |
| A | TYR43 |
| A | ASP80 |
| A | TYR507 |
| A | TYR535 |
| A | HIS541 |
| A | HIS545 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LEU D1601 |
| Chain | Residue |
| D | MET40 |
| D | PHE41 |
| D | PRO42 |
| D | TYR43 |
| D | TYR507 |
| D | HIS541 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGdLHMGHL |
| Chain | Residue | Details |
| A | PRO42-LEU53 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a8h |
| Chain | Residue | Details |
| A | VAL637 | |
| A | LYS640 |
